Fred Hutchinson Cancer Research Center, home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation, the Center's five scientific divisions collaborate to form a unique environment for conducting basic and applied science. The Hutchinson Center, in collaboration with its clinical and research partners, the University of Washington and Seattle Children's, is the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest. Join us and make a difference!
Fred Hutchinson Cancer Research Center is part of CTD² network of research centres. The Centers work independently and collaboratively as a unified "Network" to functionally validate discoveries from large-scale genomic initiatives and advance them toward precision medicine. They share data and resources, such as analytical tools and reagents, across the Network and with the research community. To learn more, visit Cancer Target Discovery And Development
We are seeking a highly motivated postdoctoral level scientist to validate novel drugs and drug targets for ovarian and breast cancer. Targets were identified by RNA interference screens: Toyoshima et al. "Functional genomics identifies therapeutic targets for MYC-driven cancer" Proc Natl Acad Sci USA, 2012 (PMID 22623531) and Kemp and Grandori, "Functional genomics to identify unforeseen cancer drug targets". Future Oncol. 9: 473-476, 2013.
The applicant will be responsible for multiple aspects of drug:drug target validation including in vitro and in vivo testing in xenografts to monitor tumor growth response, evaluation of on target and off target effects and potential general effects of experimental compounds. In vitro characterization of drugs and the effects of gene knock-down against the gene and pathways that the drug targets with the purpose of biomarker development will also be needed.
A Ph.D. in the field of molecular or cancer biology, cancer genetics, or related disciplines and a demonstrated track record of successful research and publication are required. Industry experience in drug development a plus. Technical skills needed include mouse handling, pre-clinical evaluation of drugs in xenograft models, basic molecular biology techniques, qRT-PCR, genomic PCR, Western, siRNAs and shRNA vector construction. Skills in cancer genomics, culturing human cancer cell lines and primary cultures also desirable.
Salary is based on the NIH scale and the funding for this position for at least two years is provided. Please include a cover letter detailing your research interest and suitability for this position with your application. At least two letters of recommendation will be requested as part of the screening process.
If interested, please apply online at http://track.tmpservice.com/ApplyClick.aspx?id=2336727-2647-9221