Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch's pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation's first and largest cancer prevention research program, as well as the clinical coordinating center of the Women's Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
A highly motivated postdoctoral fellowship is sought to join the lab of Chris Kemp within the Human Biology division at Fred Hutchinson Cancer Research Center in Seattle, WA. The fellow will focus on the validation of novel drugs and drug targets for ovarian and breast cancer, building off previous work by the lab (Toyoshima et al. "Functional genomics identifies therapeutic targets for MYC-driven cancer" Proc Natl Acad Sci USA, 2012 (PMID 22623531) and Kemp and Grandori, "Functional genomics to identify unforeseen cancer drug targets". Future Oncol. 9: 473-476, 2013).
The applicant will be responsible for multiple aspects of drug:drug target validation including in vitro and in vivo testing in xenografts to monitor tumor growth response, evaluation of on target and off target effects and potential general effects of experimental compounds. In vitro characterization of drugs and the effects of gene knock-down against the gene and pathways that the drug targets with the purpose of biomarker development will also be needed.
Fred Hutchinson Cancer Research Center is part of CTD² network of research centres. The Centers work independently and collaboratively as a unified "Network" to functionally validate discoveries from large-scale genomic initiatives and advance them toward precision medicine. They share data and resources, such as analytical tools and reagents, across the Network and with the research community. To learn more, visit Cancer Target Discovery And Development.
Successful applicants will have:
- A PhD in molecular biology, cancer biology, cancer genetics, or a related discipline
- A strong background in standard molecular biology techniques, including qRT-PCR, siRNA, and shRNA vector construction
- Experience with preclinical xenograft models
- Experience in cancer genomics, human cell culture, and primary cell culture is highly desired
- Industry experience with drug development is highly desired
- Demonstrated track record of productive research
Salary is commensurate with experience and based on NIH scale.
Please include a cover letter detailing your research interest and suitability for this position with your application. At least two letters of recommendation will be requested as part of the screening process.
If interested, please apply online at http://track.tmpservice.com/ApplyClick.aspx?id=2360033-2647-6721