A laboratory in Fred Hutchinson Cancer Research Center's Translational Research Program (Public Health Sciences Division) is looking for a highly motivated Postdoctoral Research Fellow. The candidate would join the Laboratory for the Study of Metastatic Microenvironments (LSM2), directed by Dr. Cyrus Ghajar. The LSM2 focuses on understanding the biology underlying disseminated tumor cell (DTC) dormancy (see Ghajar et al., Nature Cell Biology 2013) and uncovering means to eradicate dormant DTCs.
The candidate will conduct research aimed at understanding chemoresistance displayed by dormant DTCs and uncovering the microenvironmental basis for chemoresistance. The goal of this research is to develop strategies to eradicate these cells. To do so, the candidate will utilize an array of innovative and sophisticated techniques including three-dimensional cell culture models, murine metastasis models and intravital imaging approaches. The ideal candidate would be interested applying these techniques to better understand tumor-microenvironment interactions and therapeutic resistance in the context of metastatic sites.
A recent Ph.D. in the field of biochemistry or biophysics is highly desired, but candidates with backgrounds in bioengineering and molecular and/or cellular biology will be considered. In all cases, a demonstrated track record of productive doctoral research is required. A strong publication record and eligibility and desire to apply for future fellowships are also required. The candidate must also be experienced in essential techniques such as cloning, transfection/infection of cells, tissue culture (2D and 3D approaches), immunohistochemistry and immunofluorescence, and imaging.
The successful candidate must have excellent communication and organizational skills, the ability to develop creative approaches to experimental design, and thrive both in independent research and while working collaboratively.
- A candidate with experience in live cell imaging, developing quantitative image analysis approaches, and experience working in murine tumor or metastasis models is strongly desired.
- Candidates are strongly encouraged to submit a cover letter or research interests description describing their interests in the labs work.
If interested, please apply online at http://track.tmpservice.com/ApplyClick.aspx?id=2201385-2647-9021