Fred Hutchinson Cancer Research Center, home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation, the Center's five scientific divisions collaborate to form a unique environment for conducting basic and applied science. The Hutchinson Center, in collaboration with its clinical and research partners, the University of Washington and Seattle Children's, is the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest. Join us and make a difference!
We are seeking a postdoctoral fellow to investigate signal transduction during the development of the mammalian brain. Division of multipotent neuronal progenitors gives rise to undifferentiated neurons or transit amplifying cells that are committed to generate restricted neuronal subtypes. The pre-specified neurons then migrate to different locations within the developing brain where they differentiate, giving rise to distinctive layered regions including the neocortex, hippocampus and cerebellum. The migrations and final locales are regulated by intrinsic and extrinsic factors, including the Reelin signaling molecule.
Potential projects include:
- Understanding the roles of Reelin and N-cadherin during the transition of neocortical neurons from random to radial migration.
- Identifying the Cullin5-RING ligase (CRL5) adaptors (SOCS proteins) that regulate the migrations of different classes of neurons.
- Analyzing cerebellar development: Determining the roles of Reelin, CRL5 and other factors during formation of the Purkinje plate and its subsequent thinning to form the Purkinje cell layer.
- Using mutant mouse strains to identify other roles of CRL5 and SOCS proteins during development and in adult life.
The successful candidate will be expected to develop, optimize and implement experimental procedures, plan, execute and interpret experiments, present results at scientific conferences and publish findings in peer-reviewed journals, and participate fully in lab and center-wide scientific meetings. The research is supported by the National Institute for Neurological Diseases and Stroke, but the trainee will be expected to also compete for independent fellowship support.
PhD degree or equivalent. Ideally less than 1-2 years prior postdoctoral experience. Requires published evidence of productivity in molecular, cellular or developmental biology research. Experience with current approaches in cell/developmental biology research. Interest and commitment to research. Ability to communicate effectively orally and in writing. Experience with developmental neuroscience methods.
Ideally, candidates will have strong analytical skills, scientific acumen, collaborative spirit, and technical excellence. Familiarity with general methods of molecular and mammalian cellular biology and microscopy is required. Experience with rodent developmental biology techniques, including use of conditional mutants and rodent surgeries, preferred. Strong verbal and written communication skills are necessary. Ability to work independently and as part of a team is essential. Applicants should have a demonstrable ability to perform high quality research, as manifested by a strong publication record and outstanding letters of recommendation.
If interested, please apply online at http://track.tmpservice.com/ApplyClick.aspx?id=2170994-2647-10021