Fred Hutchinson Cancer Research Center, home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation, the Center's five scientific divisions collaborate to form a unique environment for conducting basic and applied science. The Hutchinson Center, in collaboration with its clinical and research partners, the University of Washington and Seattle Children's, is the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest. Join us and make a difference!
A Postdoctoral position is available in the MacPherson Lab at Fred Hutchinson Cancer Research Center. The project is focused on the biology of small cell lung cancer (SCLC), a neuroendocrine tumor type that shows remarkable initial sensitivity to chemotherapy but invariable emergence of chemoresistance. We are interested in understanding the development of resistance to chemotherapy and in generating novel targeted therapies to combine with chemotherapy. The lab has a large panel of SCLC patient samples and has developed new mouse models of SCLC that can be used to link tumor genotype with therapeutic
The candidate will use advanced mouse models as well as clinical samples to compare genomic changes that are acquired with the emergence of chemoresistance in SCLC. Molecular studies will be employed to understand signaling pathways altered by chemoresistance-driving genomic changes. Cell based screens may be employed to identify vulnerabilities associated with specific genetic alterations. Circulating tumor cells from SCLC patients may also be analyzed in the project.
We are looking for a highly motivated, recent Ph.D. graduate with interest in cancer genetics and mouse models. A strong foundation in molecular and cell biology is essential. Experience in one or more of the following areas is desirable: mouse genetics; genomics; study of circulating tumor cells; functional genomics.
We are a VEVRAA Federal Contractor.
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