We are looking for genomics researchers with a keen interest in studying the role of microbes in skin diseases. The Nagarajan lab in the Genome Institute of Singapore, in collaboration with the Epithelial Biology group in the Institute of Medical Biology are seeking candidates to lead multiple projects studying the role of the microbiome in inflammatory diseases of the skin (e.g. eczema, psoriasis etc.). Successful candidates will have the opportunity to design new studies in close interaction with doctors and domain experts, applying nextgen omics and analytical approaches to understand the complex host-microbiome interactions that lead to skin disease .
The role that microbes play on human skin is still poorly understood despite characterization of the diversity of habitats and niches that they occupy . This is particularly the case for skin diseases which can affect a large proportion of the population and have a significant impact on their quality of life. We recently conducted a metagenome-wide association study for eczema, identifying key microbes and their likely functional roles . We are interested in extending this work in several directions including (i) characterizing the utility of pre-/probiotic therapies (ii) developing in vitro and in silico models for host-microbiome interactions  and (iii) studying the role of fungi (e.g. Malassezia) on human skin .
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 Li C, Lim KM, Chng KR, Nagarajan N# "Predicting microbial interactions through computational approaches." Methods 2016 Jun 1 ; 102 : 12-9 Epub 2016 Mar 26
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