Post-doctoral Fellowship in Skin Microbiome Studies

Organization
Genome Institute of Singapore
Job Location
Singapore
Job Description

We are looking for genomics researchers with a keen interest in studying the role of microbes in skin diseases. The Nagarajan lab in the Genome Institute of Singapore, in collaboration with the Epithelial Biology group in the Institute of Medical Biology are seeking candidates to lead multiple projects studying the role of the microbiome in inflammatory diseases of the skin (e.g. eczema, psoriasis etc.). Successful candidates will have the opportunity to design new studies in close interaction with doctors and domain experts, applying nextgen omics and analytical approaches to understand the complex host-microbiome interactions that lead to skin disease [1].

The role that microbes play on human skin is still poorly understood despite characterization of the diversity of habitats and niches that they occupy [2]. This is particularly the case for skin diseases which can affect a large proportion of the population and have a significant impact on their quality of life. We recently conducted a metagenome-wide association study for eczema, identifying key microbes and their likely functional roles [1]. We are interested in extending this work in several directions including (i) characterizing the utility of pre-/probiotic therapies (ii) developing in vitro and in silico models for host-microbiome interactions [3] and (iii) studying the role of fungi (e.g. Malassezia) on human skin [4].

References

[1] Chng KR, Tay ASL, Li C, Ng AHQ, Wang J, Suri BK, Matta AS, McGovern N, Janela B, Wong XFC, Sio YY, Au BV, Wilm A, De Sessions PF, Lim TC, Tang MBY, Ginhoux F, Connolly JE, Lane EB, Chew FT, Common JEA#, Nagarajan N# "Whole metagenome profiling reveals skin microbiome-dependent susceptibility to atopic dermatitis flare" Nature Microbiology 2016 1:16106 doi:10.1038/nmicrobiol.2016.106

[2] Oh, J. et al. "Biogeography and individuality shape function in the human skin metagenome." Nature 2014 514, 59–64

[3] Li C, Lim KM, Chng KR, Nagarajan N# "Predicting microbial interactions through computational approaches." Methods 2016 Jun 1 ; 102 : 12-9 Epub 2016 Mar 26

[4] Wu G, Zhao H, Li C, Rajapakse MP, Wong WC, Xu J, Saunders CW, Reeder NL, Reilman RA, Scheynius A, Sun S, Billmyre BR, Li W, Averette AF, Mieczkowski P, Heitman J, Theelen B, Schröder MS, De Sessions PF, Butler G, Maurer-Stroh S, Boekhout T, Nagarajan N#, Dawson TL# "Genus-Wide Comparative Genomics of Malassezia Delineates Its Phylogeny, Physiology, and Niche Adaptation on Human Skin." PLoS Genet 2015 Nov ; 11(11) : e1005614 Epub 2015 Nov 5

Requirements

PhD in Microbiology/Skin Biology/Computational Biology
Strong analytical skills and programming background. Candidates with significant experience in Microbiome Studies or Skin Biology will be strongly preferred.

About Our Organization

The Genome Institute of Singapore (GIS) is the national flagship program for the genomic sciences in Singapore with a mission to use genomic sciences to improve public health and national prosperity. Singapore is a highly cosmopolitan city-state at the cross-roads of Asia with one of the highest standards of living in the world. GIS provides a competitive remuneration package and relocation assistance.

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