Post-doctoral Fellowship in RNA Structural Genomics

Organization
Genome Institute of Singapore
Job Location
Singapore
Job Description

 

We are seeking highly qualified computational scientists with expertise/interest in RNA structure and biology. The Nagarajan Lab, in collaboration with the Wan Lab at the Genome Institute of Singapore are looking for applicants to direct collaborative projects involving the development of new algorithms and the analyis of novel high-throughput, genome-scale RNA structure datasets. Successfull candidates will work in a highly inter-disciplinary environment to apply cutting edge techniques in computational and experimental genomics for achieving breakthrough discoveries that significantly advance human health and well-being.

RNA structure is fundamental to its function in almost every cellular process and for understanding disease biology. We have developed new approaches to probe RNA secondary and tertiary structure genome-wide [1-4] and are applying these for a range of applications including (i) identification of new targets for developing antibiotics against extremely drug-resistant pathogens (ii) understanding host-microbial interactions in diseases and (iii) identifying structural switches that control gene regulation during stem-cell differentiation and oncogenesis. We are seeking exceptional researchers who will join us in leveraging this unique opportunity for significant basic and translational advances in RNA genomics.

References

  1. Kertesz M*, Wan Y*, Mazor E, Rinn JL, Nutter RC, Chang HY, Segal E "Genome-wide measurement of RNA secondary structure in yeast." Nature 2010 Sep 2 ; 467(7311) : 103-7
  2. Wan Y, Qu K, Ouyang Z, Kertesz M, Li J, Tibshirani R, Makino DL, Nutter RC, Segal E, Chang HY "Genome-wide measurement of RNA folding energies." Mol Cell 2012 Oct 26 ; 48(2) : 169-81 Epub 2012 Sep 13
  3. Wan Y.*, Qu K.*, Zhang QF, Manor O, Ouyang Z, Zhang J, Snyder MP, Segal E and Chang HY "Landscape and variation of RNA secondary structure across the human transcriptome." Nature 2014 ; 505, 706–709
  4. Aw JG, Shen Y, Wilm A, Sun M, Lim XN, Boon KL, Tapsin S, Chan YS, Tan CP, Sim AY, Zhang T, Susanto TT, Fu Z, Nagarajan N#, Wan Y# "In Vivo Mapping of Eukaryotic RNA Interactomes Reveals Principles of Higher-Order Organization and Regulation." Mol Cell 2016 May 19 ; 62(4) : 603-17 Epub 2016 May 12
Requirements
  • PhD in Computational Biology/Computer Science/Applied Mathematics/Genomics
  • Strong analytical and programming skills (C/C++, perl/python, UNIX environment). Candidates with significant experience in RNA structure prediction will be strongly preferred.
About Our Organization

The Genome Institute of Singapore (GIS) is the national flagship program for the genomic sciences in Singapore with a mission to use genomic sciences to improve public health and national prosperity. Singapore is a highly cosmopolitan city-state at the cross-roads of Asia with one of the highest standards of living in the world. GIS provides a competitive remuneration package and relocation assistance.

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