Dr. Kendall Van Keuren-Jensen, an Associate Professor at TGen is working on the identification and analysis of circulating cell-free RNA. Extracellular RNAs are released from all cell types and are protected from degradation by association with vesicles or RNA-binding proteins. Typically access to cells in the Central Nervous System (CNS), such as neurons in the brain or spinal cord, is difficult or impossible. Circulating cell-free RNAs as indicators (snapshots) of disease-relevant information are carried from these inaccessible tissues to the periphery, making them attractive candidates for monitoring CNS diseases. A recent proof-of-concept publication from the Jensen lab verified that RNAs associated with neuropathology in the brain are present and detectable in peripheral body fluids. Our goal is to use circulating molecular material to monitor disease pathogenesis quickly and non-invasively to improve treatments.
Ensures the design, development, execution, and implementation of scientific research and/or development in collaboration with a research team.
Works under general direction while initiating, performing or conducting research experiments.
Integrates and implements experimental design.
Performs data analysis and prepares reports.
Writes manuscripts for publications. Assists in writing proposals.
Mentors junior level team members.
Coordinates with other research groups and institutions on collaborative studies.