About the lab:
Computational genomics - Francesco Ferrari lab
IFOM, Milan, Italy (http://www.ifom.eu)
We are a computational biology group specialized in the development and adoption of novel computational solutions for functional genomics high-throughput data. We study epigenetics and transcription regulation using genome-wide data in different experimental models.
Examples of current projects include:
1) Short range chromatin loops. We are working on identifying and characterizing short-range chromatin loops involved in regulating transcription, by using high-resolution genome-wide chromatin architecture data. We will be working both on model organisms and cancer samples.
2) Dynamic chromatin changes. We are working on methods to identify new chromatin regulatory elements by focusing on dynamic changes in chromatin marks occurring during cell identity transitions, including reprogramming and cancer progression models.
3) Epigenetics and transcription regulatory modules. We are working on the integration of large genome-wide datasets to identify modules of genes and chromatin regulatory elements (e.g. enhancers and promoters) to be used as reliable markers of cell identity. In addition to large public datasets, we'll be working both on in vitro differentiation and direct conversion experimental models.
About the Institute:
Founded in 1998 by FIRC (Italian Foundation for Cancer Research), IFOM is a research institute focused on the study of cancer formation and development at molecular level.
IFOM is located close to the city center within a campus shared with two other research institutions: IEO (European Institute of Oncology) and the Center for Genomic Science of IIT (Italian Institute of Technology). The institute is equipped with state of the art molecular biology laboratories and shared facilities within the campus with the latest technologies for genomics experiments. The campus hosts a well renowned PhD program (SEMM), which attracts many talented students from throughout Italy and abroad.
With its Universities, renowned research centers and clinical institutes, Milan is at the heart of a vibrant scientific environment with a dynamic community of researchers and students coming from all over the world.