Post-doctoral position is currently available in the dos Santos lab.
The laboratory of Camila dos Santos is seeking a highly motivated postdoc fellow to investigate the epigenetic control of normal and malignant mammary gland development. Significant changes mark the pre- and post-pubescence mammary developmental stages, but those associated with pregnancy have the greatest effect on cellular function, tissue reorganization, and breast cancer susceptibility.
Our group has recently found that mammary glands react differently to a second pregnancy than they do to the first one, with associated changes in DNA methylation. These affected regulatory regions that modulate mammary stem cell self-renewal, lineage specification, and potentially cell transformation. We are now building upon these findings to understand how the pregnancy-induced epigenetic changes might influence cell transformation and the risk of breast cancer.