PhD position Bioinformatics: Infection associated tumorigenesis

Organization
Max-Planck-Institute for Infection Biology, Berlin
Job Location
Charitéplatz 1
10117 Berlin
Germany
Job Description

The Max Planck Institute for Infection Biology (MPIIB), Department of Molecular Biology, Berlin, Germany, is seeking for the earliest possible start date a PhD Student in Bioinformatics for a project developing bioinformatics tools and for the analysis of deep sequencing data of host (epi-)genetic modifications of the human genome.

During the last few years, the advent of next generation sequencing has allowed to analyze mutational changes in tumors and normal tissues in unprecedented detail. Analysis of large cohorts of tumor samples allowed to define several mutational signatures thought to be linked to specific mutational processes, active at some time point in the history of the tumour. Mutational signatures could therefore be a means to decipher driving mutational processes at tumour initiation or progression in vivo and in vitro.

We seek a highly motivated candidate to contribute to challenging projects and to establish novel bioinformatics methods that allow characterizing current or past mutational processes and to estimate its magnitude from sequencing data. Specifically, methods will be developed for and applied to sequencing data sets in the area of infection biology to characterize transient and permanent changes to the (epi)genome of host cells after contact with various pathogens.

Requirements

A suitable applicant will have a diploma or master’s degree in Bioinformatics, Mathematics, Computer Science, Physics, Statistics or Biology with strong computational skills. The candidate should be experienced in the statistics package R/Bioconductor and familiar with a scripting language such as PERL or Python. Knowledge of high-level languages (e.g. Java, C++) and familiarity with SQL Databases (MySQL, Postgres) is desirable. Experience with computational work should be complemented by a good understanding of biological questions and data sets. Expertise in sequencing data analysis is advantageous. Excellent communication and team player skills are indispensable.
The successful candidate will work as part of an innovative, multidisciplinary and dynamic research team with state-of-the-art facilities, located within a vibrant city environment. The PhD Project will be conducted in close collaboration with professional experts. PhD training and position will be offered for up to three years.

The Max Planck Society is committed to employing more handicapped individuals and especially encourages them to apply. The Max Planck Society seeks to increase the number of women in areas where they are underrepresented and therefore explicitly encourages women to apply.

How to Apply

Applications will be accepted exclusively via our online application portal. Please follow the link:

https://recruitingapp-5133.de.umantis.com/Vacancies/283/Application/New/...

Please upload a cover letter, CV, publication list and names and addresses of at least three referees by 21.06.2015.

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