The Max Planck Institute for Infection Biology (MPIIB), Department of Molecular Biology, Berlin, Germany, is seeking for the earliest possible start date a PhD Student in Bioinformatics for a project developing bioinformatics tools and for the analysis of deep sequencing data of host (epi-)genetic modifications of the human genome.
During the last few years, the advent of next generation sequencing has allowed to analyze mutational changes in tumors and normal tissues in unprecedented detail. Analysis of large cohorts of tumor samples allowed to define several mutational signatures thought to be linked to specific mutational processes, active at some time point in the history of the tumour. Mutational signatures could therefore be a means to decipher driving mutational processes at tumour initiation or progression in vivo and in vitro.
We seek a highly motivated candidate to contribute to challenging projects and to establish novel bioinformatics methods that allow characterizing current or past mutational processes and to estimate its magnitude from sequencing data. Specifically, methods will be developed for and applied to sequencing data sets in the area of infection biology to characterize transient and permanent changes to the (epi)genome of host cells after contact with various pathogens.