NGS Scientist Nucleotide Chemist (4386) | GenomeWeb

NGS Scientist Nucleotide Chemist (4386)

Job Location
Waltham, MA
Job Description

We are seeking candidates who will assist in the design, synthesis, purification and scale up production of nucleotides. The successful candidate will be integral part of the NGS consumables department and will be responsible for design, implementation and optimization of synthesis pathways, scale up and development of SOPs as well as transferring manufacturing procedures to operations. This person will be interacting closely with the operations/manufacturing team as well as sequencing chemistry and enzyme development team.

The Scientist will:

• Plan and execute complex synthesis of proprietary nucleotide triphosphates at micro to milimolar scale
• Perform scale up of synthesis and purification of nucleotide triphopshates up to milimolar scale
• Interface with manufacturing and operations to ensure transfer of procedures
• Develop improvements in the design, synthesis and purification of nucleotide triphosphates
• Contribute to the development of intellectual property
• Collaborate closely with sequencing chemistry development group and other functional areas to meet project objectives
• Write technical reports and scientific publications/posters
• Produce and maintain proper project documentation in accordance with internal and external requirements


 MS or PhD or equivalent in Organic Chemistry
• Relevant industry experience: at least 3+ years industry experience
• Strong hands-on experience in complex multi-step organic synthesis and synthesis purification of nucleotides
• Experience with Sequencing by Synthesis technology
• Experience with nucleotide triphosphate synthesis and purification at micro/milimolar scale
• Extensive experience with chromatographic purification techniques, such as ion-exchange, reverse phase and analytical methods such as LC-MS and NMR
• Proven ability to design, execute and correctly intepret complex experiments
• Excellent verbal and writing skills, Excellent organizational skills
• Strong technical writing and presentation skills, prepare data for presentation and present data in lab meetings and to internal collaborators
• Good troubleshooting and problem solving skills
• Experience with product development under design control is preferred
• Minimal travel required (up to 10%)

How to Apply

If interested, please apply online

About Our Organization

As the innovative market and technology leader, QIAGEN creates sample and assay technologies that enable access to content from any biological sample.

Our mission is to enable our customers to achieve outstanding success and breakthroughs in life sciences, applied testing, pharma, and molecular diagnostics. We thereby make improvements in life possible.

Our commitment to the markets, customers, and patients we serve drives our innovation and leadership in all areas where our sample and assay technologies are required.

The exceptional talent, skill, and passion of our employees are key to QIAGEN’s excellence, success and value.

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