Next Generation Sequencing Technician or Technologist

Organization
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
Job Location
1090 Vienna
Austria
Job Description

The Biomedical Sequencing Facility is Austria’s leading technology platform and research service provider dedicated to next generation sequencing in biomedicine. It is jointly run by the Medical University of Vienna and the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences. To keep up with rapid growth, we are now hiring a Next Generation Sequencing Technician or Technologist who will operate the latest genomics equipment and contribute to cutting-edge biomedical research and service provision for whole genome medicine.

The Candidate
We are looking for highly motivated, well-organized, and hard-working candidates who feel comfortable working in a highly dynamic and ambitious research environment. The work involves handling a large number of collaborations and customers in parallel, thus requiring the ability to effectively multi-task as well as stress resistance, friendliness, and a collaborative mindset. A typical candidate would have a Bachelor or Master degree in the life sciences and prior experience doing wet-lab work in a demanding environment. Candidates with a TA/MTA diploma or with a PhD will also be considered. Tasks and pay are commensurable with experience and skills. We take career development of our staff seriously at CeMM. For example, we will train the successful candidate in various state-of-the-art technologies that are in high demand in both academia and industry, and we encourage substantial contribution and co-authorship for publications in top journals. It is expected that genomic medicine will be an area of major growth in Austria and internationally (cf. Obama’s recent announcement of a massive precision medicine initiative), thus creating a highly promising area for career development. 

Typical Tasks

  • Running the sequencers. Operating the Illumina HiSeq/MiSeq sequencers on a routine basis at the best possible quality
  • Library preparation. Preparing samples for genome, epigenome, and transcriptome sequencing (manually or using robotics)
  • Collaborations and customer support. Interacting with researchers who send their samples for sequencing
  • Troubleshooting. Detecting and resolving technical problems with the machines and with low-quality samples
  • Protocol optimization. Establishing and testing new protocols, often in close collaboration with customers
  • Lab management. Keeping track of samples and stocks, contributing to order management and service billing
  • Training and outreach. Contributing to workshops and teaching collaborating scientists how to prepare their samples
  • Genom Austria. Depending on interest, work with CeMM’s citizen science project on personal genomes could be part of the job

 

The Biomedical Sequencing Facility (http://biomedical-sequencing.at)
The successful candidate will be based at the Biomedical Sequencing Facility (BSF) at CeMM. The BSF is Austria’s first and leading center of expertise for next generation sequencing in biomedicine. Under the leadership of Christoph Bock (http://christoph-bock.org/) and with a dedicated team of staff scientists, the BSF contributes to biomedical research and whole genome medicine in Vienna, Austria, and internationally. The BSF also performs the genome sequencing and analysis for Genom Austria (http://genomaustria.at/), which is the Austrian Personal Genome Project (http://www.personalgenomes.org/austria). The BSF is equipped with the latest technology for large-scale genome research, including: (i) three Illumina HiSeq sequencers for production sequencing; (ii) an Illumina MiSeq sequencer for technology development and gene panels; (iii) a PerkinElmer Sciclone NGS (pre-PCR) and Zephyr (post-PCR) robotics system supporting 96-well automated library preparation for RNA-seq (PolyA+, RiboZero, and QuantSeq 3’mRNA fingerprinting), RRBS, and ChIP-seq; (iv) a Silicon Biosystems DEPArray and a Fluidigm C1 for single-cell RNA and DNA methylation sequencing. The BSF is also part of the Oxford Nanopore early access program. It is supported by a powerful scientific computing cluster that is upgraded annually to keep pace with steeply increasing amounts of data generation (current status: >100 CPUs, >1,000 cores, >10 TB memory, >1,000 TB storage). The BSF’s mandate includes a strong focus on technology development, contribution to study design and bioinformatic data analysis, as well as training and teaching best practices in sequencing technology and genomic medicine.

About Our Organization

The CeMM Research Center for Molecular Medicine is an international and interdisciplinary research institute of the Austrian Academy of Sciences. Driven by medical needs, CeMM integrates basic research and biomedical expertise to pursue innovative diagnostic and therapeutic approaches focused on cancer, inflammation, and immune disorders. CeMM is located in a new building at the center of Vienna’s Medical University campus, within walking distance of Vienna’s historical city center. According to a recent study by “The Scientist”, CeMM is among the top-5 best places to work in academia world-wide (http://the-scientist.com/2012/08/01/best-places-to-work-academia-2012). Vienna is frequently ranked the world’s best city to live. It is a United Nations city with a large English-speaking community. The official language at CeMM is English, and more than 30 different nationalities are represented at the institute.

 

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