Next Generation Sequencing Scientist (Hyb & Seq) | GenomeWeb

Next Generation Sequencing Scientist (Hyb & Seq)

Organization
NanoString Technologies
Job Location
500 Fairview Ave
Seattle, WA 98109
Benefits

Nanostring offers competitive benefits including but not limited to:

Medical, dental, 401k, stock options, ESPP

Job Description

NanoString Technologies is seeking a highly motivated and technology-savvy molecular biologist/biochemist, who will join R&D's New Technology Development group.  This position will have a central role on the development of sequencing chemistry used in the Hyb & SeqTM technology, a novel single-molecule hybridization-based next generation sequencing (NGS).  She or he will act as, at times, lead scientist and will interact/coordinate with a highly interdisciplinary group of technologists to achieve complex technical goals.  Successful candidate must be passionate about wet-lab driven experimentations to find innovative solutions to development hurdles.  Candidate must have strong analytical skills, strong oral and written communication skills, and strong track record of independent as well as collaborative research.

Essential Functions:

  • Apply advanced and expert scientific knowledge to sequencing chemistry development project
  • Take initiatives to conceive, design and carry-out hypothesis driven feasibility experiments, understanding both theoretical and practical aspects of the experimental design
  • Drive wet-lab experimentation and subsequent data analysis/interpretation activities
  • Work interactively with biophysicists, nucleic-acid chemists, fluorescence imaging specialists, and hardware/software engineers
Requirements
  • Ph.D. in Life/Chemical/Physical/Engineering Sciences
  • 5+ years of industrial and/or post-doctoral work experience in NGS technology development
  • Extensive hands-on, state-of-the-art molecular biology experience
  • Track-record of working with novel synthetic chemistry and/or surface chemistry to improve nucleic acid manipulations
  • Broad knowledge of nucleic acid characterization techniques, especially hybridization-based assays
  • Experience with fluorescence-based detection technologies including single molecule detection
  • Able to develop biological/chemical reagents and methods as needed
  • Able to identify and evaluate commercial technologies to determine their appropriateness and usefulness in technology innovation/development

 

Additional Qualifications include:

  • Experience working with microfluidic devices
  • Familiarity with NGS bioinformatics
About Our Organization

NanoString Technologies is a publicly held provider of life science tools for translational research and molecular diagnostics. The company's technology enables a wide variety of basic research, translational medicine and in vitro diagnostics applications.

NanoString's products are based on a novel digital molecular barcoding technology invented at the Institute for Systems Biology (ISB) in Seattle under direction of Dr. Leroy Hood. The company was founded in 2003 with an exclusive license to develop and market the technology. In 2008, NanoString launched its first commercial instrument system and began international sales operations with its first multiplexed assays for gene expression analysis. In 2010, the company launched new applications for the system to support microRNA analysis and copy number variation detection, and in 2013 launched Prosigna®, its first in vitro diagnostic product for prognosis of early stage breast cancer.

Organizations performing cancer research, biomarker validation and screening, and next-generation sequencing validation are rapidly adopting the nCounter® Analysis System. By providing simple, multiplexed digital profiling of single molecules, the NanoString platform represents a natural, digital downstream companion to next-generation sequencing and enables researchers to embark on studies that were previously inconceivable.

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