Molecular Biologist/Geneticist - Circulating tumor DNA profiling

Organization
Memorial Sloan Kettering Cancer Center
Job Location
1275 York Avenue
New York, NY 10065
Salary
https://www.mskcc.org/education-training/postdoctoral/current-incoming/appointment-ranks
Benefits

Our postdocs enjoy competitive compensation and benefits. We also have an extensive support program to help you get settled after your arrival in New York City, and manage your work and professional life successfully throughout your training.

https://www.mskcc.org/education-training/postdoctoral/compensation-benef...

Job Description

https://www.mskcc.org/research-areas/labs/dana-tsui/molecular-biologist-...

We are looking for a molecular biologist/geneticist to develop assays for profiling circulating nucleic acids (DNA/RNA) in body fluids (plasma, urine, CSF) , or so-called "Liquid Biopsy", of different cancer types. 

Description of this role

The successful candidate will participate in projects to achieve 3 goals: (1) develop molecular assays to profile circulating tumor DNA (ctDNA) from body fluids and (2) evaluate its utility in different solid cancer types (3) study the biological characteristics of circulating tumor DNA in body fluids (Research focuses of the lab are here).

For (1), the types of assays we develop include targeted deep sequencing, exome sequencing and whole genome sequencing, depending on tumor types and the genomic coverage/detection sensitivity required for different clinical questions. Prior experience on applying any of these technologies on human tissues (tumor/FFPE) or body fluids (plasma, urine, saliva, CFS) in pregnancy or pathological conditions (not limited to cancer) will be necessaryUnderstanding of the different molecular strategies for mutation detection and quantification is critical.

For (2 and 3), we work with a variety of solid tumor teams and clinical trial teams across MSKCC to address different questions (examples here – we collect longitudinal samples and aim to compare ctDNA dynamics with clinical responses to evaluate its informatively on treatment decision.  The possible cancer types include: prostate, breast, brain, bladder and ovarian, and the list is expanding. Basic understanding of cancer genomics will be necessary.

Assay development will be a jointed effort with the Innovation Laboratory of the Center for Molecular Oncology, Molecular Diagnostic Service Team and Department of Laboratory Medicine. Clinical evaluation will be done in close collaboration with individual research groups and clinical trials teams. The ideal candidate will be a team-player with excellent communication and interpersonal skills.

 

We are not looking for someone who only follows protocols. We want an inventor with a creative mind. Join us if you think you are good and want to make an impact. 

Memorial Sloan Kettering Cancer Center is an equal opportunity employer with a strong commitment to enhancing the diversity of its faculty and staff. Women and applicants from diverse racial, ethnic and cultural backgrounds are encouraged to apply.

Requirements

Laboratory techniques:

  • Nucleic acids extraction (DNA/RNA),
  • PCR, digital PCR,
  • DNA quantification,
  • Library preparation (whole-genome / exome / targeted / DNA methylation) for massively parallel sequencing (next-generation sequencing, NGS), or relevant experience.

 

Statistical knowledge:

Knowledge of biomedical statistics, and experience with statistics programmes such as R, SPSS, Prism, etc.

Computational techniques:

  • Experience with document-processing programmes such as Microsoft Office (Excel, Word, Powerpoint), etc.
  • Scientific figures management such as Adobe Illustrator, Inkscape, etc. is a plus
  • Experience with programming skill, such as R, Python, MatLab, etc, is a plus.

 

 

How to Apply

If you are interested in joining our lab, please prepare the following:

- Curriculum vitae
- Cover letter detailing your past research experience, accomplishments, current motivation and future research interests. Include your expected availability date
-Names and contact information of three referees.

Address all inquiries to Dana Tsui c/o Yessie Werner at [email protected].

Mailing Address
Dana Tsui, PhD
c/o Yesenia Werner
Memorial Sloan Kettering Cancer Center
1275 York Avenue, Box 20
New York, NY 10065
USA

About Our Organization

Memorial Sloan Kettering Cancer Center offers first-rate research training for postgraduate biomedical scientists and for clinician-scientists who are in the training stages of their careers.

We are committed to helping you gain the experience, skills, and credentials you will need to join a new generation of scientific leaders. In addition to laboratory research training, we offer an extensive career development program to help you achieve your individual goals.

Postdoctoral researchers at Memorial Sloan Kettering work alongside some of the world’s leading scientists. In addition, the Center is home to more than 35 state-of-the art core facilities that foster highly productive research.

 

https://www.mskcc.org/education-training/postdoctoral

 

 

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