Mass Spectrometry Newborn Screening Chemist

North Carolina State Laboratory of Public Health
Job Location
4312 District Dr
Raleigh, NC 27607
$46,206 to $50,972

For permanent appointments:

State of North Carolina employees have the opportunity to participate in a compelling array of benefits to enhance their quality of life, their health, and their future. Benefits include a free employee health insurance option, standard and supplemental retirement plans, NC Flex (a variety of high-quality, low cost benefits on a pre-tax basis), and paid vacation, sick, and community service leave, to name a few.  Some benefits require 30 + hours work/week for participation. To find out about these, and other programs, please visit our Employee Benefits page:

Job Description

he primary purpose of Newborn Screening (NBS) Unit in the State Laboratory of Public Health (SLPH) is to provide timely and accurate testing to detect potentially fatal or disabling conditions in newborns.  Identifying infants with these conditions early in life provides a window of opportunity for treatment, often before the infant displays any signs or symptoms of the disease or condition. 
This Newborn Screening MS/MS Chemistry II position is assigned to the Tandem Mass Spectrometry (MS/MS) group within the Newborn Screening Unit of the State Lab of Public Health.  The position is responsible for performing dried blood spot (DBS) screening on newborns in the state of North Carolina for Fatty Acid Oxidation Disorders, Organic Acid Disorders, and Amino Acid Disorders.  The primary function of the MS/MS group is to perform accurate and timely screening analyses on clinical specimens collected from newborns using analytical and biochemical procedures and electrospray tandem mass spectrometry quadrupole technology.  Analysis and intricate interpretation of data derived from clinical specimens by qualitative and quantitative methods identifies infants with metabolic disorders that if delayed, undetected or untreated, cause irreversible mental and physical incapacities or even death

Additionally, identified children and adults are monitored for their responses to dietary and medical treatment.  The service is provided to physicians, birthing hospitals, local health departments and other health care providers.  The NBS Unit also collaborates with universities and other institutions on various data mining and method development projects and pilot studies to enhance the NBS program and the NCSLPH testing menu to accommodate for new disorders and/or methodologies as they become available.


The successful candidate must have:

  • Experience with Mass Spectrometry laboratory instrumentation (LC/MS) and other analytical chemistry equipment and instrumentation, including experience in using terminology associated with the technology.
  • Experience with analytical troubleshooting, performing root cause analysis, and implementing corrective actions to improve test procedures and instrument functionality.
  • Experience maintaining a Quality Assurance Program which includes: proficiency testing, quality control standards and the use of standard operating procedures.
  • Experience working effectively within a team.
  • Experience interpreting large data sets and conducting trend analysis.
  • Superb organizational skills that will allow for the coordination of multifaceted testing activities.
  • Experience conducting independent work with minimal supervision.
  • Experience reviewing, interpreting and reporting laboratory testing results according to federal and state regulations and program guidelines.
  • Thorough knowledge of federal CLIA, OSHA and state governmental standards and regulations.
  • Experience working with potentially infectious material and must know and apply the appropriate precautions.
  • Demonstrated ability to express technical information clearly and concisely both verbally and in writing using Microsoft Office products.
About Our Organization

Mission Statement

The State Laboratory of Public Health provides certain medical and environmental laboratory services (testing, consultation and training) to public and private health provider organizations responsible for the promotion, protection and assurance of the health of North Carolina citizens.


  • Provide quality-assured laboratory services
  • Assist other North Carolina laboratories in developing and strengthening their laboratory services
  • Serve the entire state as a reference laboratory for difficult, unusual or otherwise unavailable laboratory procedures
  • Serve as a resource of information on laboratory practice
  • Test human and related animal specimens and environmental samples
  • Assist in the development, evaluation, and standardization of medical and environmental laboratory testing procedures
  • Participate in special studies and research projects
  • Provide training, consultation and information updates, to improve and assure quality services in other laboratories
  • Certify milk and water laboratories and milk analysts

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