Manufacturing Technician, Reagent Manufacturing

Twist BioScience
Job Location
San Francisco, CA
Job Description

W­­e are seeking candidates interested in working for an exciting start-up company located in South San Francisco. This is an ideal opportunity for individuals who thrive in a changing environment and enjoy supporting and delivering world-class products that meet both external and internal customer needs.       

This is a role for someone who craves a challenge balanced by the desire to be accountable for delivering high quality products for Twist. It is both a strategic and a tactical position. Those that do not want to get their hands dirty should not apply.

Twist is looking for a technician with skills in reagent development and manufacturing for life science products. This individual will work closely with the R&D, Process Development, and Operations teams to develop reagents that will ultimately be utilized in the Twist manufacturing centers. The Technician will be part of a team that develops reagent manufacturing processes, formulates reagents at scale, help develop QC processes, conducts stability studies and creates manufacturing SOP’s.  He/she will supply reagents to operations. This position reports to the Reagent Manufacturing Lead Scientist.

Key Responsibilities:

  • Work with the Reagent Lead to execute experimental plans, test processing parameters and assess operational boundaries
  • Maintain thorough, accurate and detailed documentation of all work produced in batch records, databases or other acceptable formats including problems and deviations
  • Collaborate with the automation team to formulate reagents in automation friendly formats
  • Build reagents to scale and test according to reagent specifications
  • Test reagents in the operations environment
  • Set up part numbers and bills of material
  • Write work instructions, SOP’s and training documents for manufacturing operators
  • Train manufacturing operators on proper reagent handling and usage
  • Ability to work independently and in a safe manner
  • Ability to clearly communicate results in verbal and written formats
  • Make Reagents and subassemblies to meet forecasted MFG Plan of Record




Minimum Qualifications:

  • BS in Biochemistry, Molecular Biology or related field
  • Industrial experience in manufacturing, biotechnology product development and/or technical transfer
  • Must be familiar with working with growing and working with cells (e. coli)
  • Must be familiar with cloning, transformation

  • Required Qualifications:

    • Ability to work in a fast paced, team environment
    • Experience with lab equipment including manual pipettes, pH meters, analytical scales, autoclaves and reagent dispensing equipment
    • Good computer skills including experience with excel, word, Jira or similar web based programs
    • Ability to operate fermentation equipment
    • Knowledge of GMP/ISO standards
    • Experience with ERP systems such as SAP, Agile, Oracle, etc.
    • Experience with automation platforms such as Hamilton/Biomek/Tecan or Echo is a plus
How to Apply
About Our Organization

At Twist Bioscience, our expertise is accelerating science and innovation by leveraging the power of scale. We have developed a proprietary semiconductor-based synthetic DNA manufacturing process featuring a 10,000-well high throughput silicon platform capable of producing synthetic biology tools, including genes, oligonucleotide pools and variant libraries. By synthesizing DNA on silicon instead of on traditional 96-well plastic plates, our platform overcomes the current inefficiencies of synthetic DNA production, and enables cost-effective, rapid, high-quality and high throughput synthetic gene production, which in turn, expedites the design, build, test cycle to enable personalized medicines, pharmaceuticals, sustainable chemical production, improved agriculture production, diagnostics, biodetection and data storage. For more information, please visit Twist Bioscience is on Twitter. Sign up to follow our Twitter feed @TwistBioscience at

Twist Bioscience is an equal opportunity employer.

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