Manufacturing Associate, Front-End

Twist Bioscience
Job Location
San Francisco, CA 94158
Job Description

We are looking for motivated, enthusiastic individuals to join our Twist Bioscience Operations Team in San Francisco. The Manufacturing Associate will be responsible for the manufacture of oligonucleotides for downstream processing and QC testing using Twist Bioscience’s proprietary process workflow and to meet the Twist production forecast and timelines.

The ideal candidate will be driven and will do what it takes to keep DNA synthesis manufacturing on track in a fast paced start-up environment.  The Manufacturing Associate will produce oligos and perform QC testing on those oligos according to established SOPs and complete manufacturing batch records to contribute to the daily production schedule. The ideal candidate will work independently, be very neat and organized, have basic knowledge and operation of equipment used in DNA synthesis, contribute to process improvement and documentation, and communicate effectively with peers and management.  Knowledge of good laboratory practices (GLPs) is important. The Candidate must be comfortable working in a LEAN manufacturing/ controlled laboratory environment.

 include but are not limited to the:

  • Manufacture high quality custom gene products in a high throughput MFG lab according to established SOPs.
  • Maintain thorough, accurate and detailed documentation/ databases of all work produced in batch records, databases or other acceptable formats  including problems and deviations.
  • Operation of automated equipment used to synthesize DNA.
  • Operation of automated liquid handling equipment.
  • Familiar with DNA phosphoramidites and mixing with solvents.
  • Moisture testing phosphoramidites.
  • Keen observation and aptitude to proactively identify production problems/solutions, provide solutions on lab techniques, protocols, processes, handling of product and equipment.
  • Upholding standards as defined by the manufacturing process.
  • Continuous improvement and good time management resulting in efficiency.
  • Support cost improvement initiatives by reducing failures, improving capacity and using supplies wisely. Reduce work in process, queues and cycle times.
  • Work in a safe manner.
  • Maintenance and calibration of select lab equipment.
  • Analytical characterization of DNA synthesis products.

 include demonstrated knowledge and/or hands on experience with basic lab techniques and equipment/ automation such as: 

  • Liquid handling
  • Experience with manual pipetting
  • Karl Fischer instrumentation
  • Oligonucleotide synthesis
  • Basic computer skills, especially with excel and MS Office products, statistics, JIRA, Confluence, SAP and MFG databases
  • Analytical Instruments:  Spectroscopy ( Qubit, Nanodrop, plate reader), HPLC, CE ( BioAnalyzer, Fragment Analyzer) 
  • Molecular biology or chemistry skills a plus
  • Somelab experience desired, preferably in MFG environment
  • Experience using equipment for DNA synthesis a plus
  • Ability to work in an ISO, GMP, LEAN mfg environment and follow the lean manufacturing concepts
  • BA or BS in biology or chemistry a plus
  • Team based laboratory environment.
  • Working in controlled laboratory environment
  • Must be able to stand for long periods of time while performing duties.
  • Must be able to work safely with chemicals and hazardous materials.
  • Must be able to lift up to 40 lbs.
  • Must be able to work outside of regular work hours/ work a flexible shift as needed

SHIFT:  7PM-730 am shift 12h day/ 3d /4d alt work week with 1 weekend day. The incumbent will be required to work this night shift; the incumbent will start on day shift until training is complete before transitioning to night shift. Those who prefer day shifts should not apply.

How to Apply

If you speak DNA and are interested joining a dynamic group, please go to and apply!

About Our Organization

At Twist Bioscience, our expertise is accelerating science and innovation by leveraging the power of scale. We have developed a proprietary semiconductor-based synthetic DNA manufacturing process featuring a 10,000-well high throughput silicon platform capable of producing synthetic biology tools, including genes, oligonucleotide pools and variant libraries. By synthesizing DNA on silicon instead of on traditional 96-well plastic plates, our platform overcomes the current inefficiencies of synthetic DNA production, and enables cost-effective, rapid, high-quality and high throughput synthetic gene production, which in turn, expedites the design, build, test cycle to enable personalized medicines, pharmaceuticals, sustainable chemical production, improved agriculture production, diagnostics, biodetection and data storage. For more information, please visit Twist Bioscience is on Twitter. Sign up to follow our Twitter feed @TwistBioscience at

Twist Bioscience is an equal opportunity and e-verify employer.

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