Manager of Next Generation Sequencing | GenomeWeb

Manager of Next Generation Sequencing

Mount Sinai Genetic Testing Lab - Connecticut
Job Location
Branford, CT
Job Description

 • Oversee and contribute to generation of large, multiplexed pools of amplicons and libraries from isolated gDNA using automated methods in a diagnostic laboratory setting. 

• Ensure accurate and timely entry of sample information into Laboratory Information Management System (LIMS). 

• Oversee and develop library construction and Next Generation Sequencing protocols using automated methods and perform Next Generation Sequencing (NGS). 

• Using established Standard Operating Procedures (SOPs), oversee library handling, tracking, and storage. 

• Use a keen attention to detail to maintain sample integrity and identification throughout entire workflow. 

• Strict adherence to local, regulatory, and quality management guidelines to ensure full compliance.

• Help guide technology transfer from MSSM R&D into production environment.

• Train new hires.


• Bachelor’s degree in life science-related discipline. 

• Experience in safe handling and disposal of potentially infectious clinical specimens in a biological safety level laboratory environment.

• 5+ years experience with standard molecular techniques:
• PCR, qPCR, electrophoretic methods, DNA quantification, purification, and pooling methods, enzymatic manipulations, and primer design. 
 • Preference will be given to those applicants with previous NGS library experience. 
 • Experience with operating and programming liquid handling systems is preferred. 

• 2+ years experience operating NGS systems. Experience with multiple platforms is a 


• Experience with developing and/or performing high complexity lab-developed tests 

(LDTs) is a plus. 

How to Apply

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About Our Organization

An extension of the Department of Genetics and Genomic Sciences and the Institute of Multiscale Biology in the Icahn School of Medicine at Mount Sinai, our state of the art next generation sequencing facility located in Branford, Connecticut utilizes a variety of cutting edge, high throughput technologies. Our laboratory will generate huge amounts of sequencing data whose interpretation has the potential to change the face of how medicine is practiced. We will participate in large sequencing projects and analyze large numbers of individuals to gain a better understanding of the biology of cancer and inherited diseases.

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