Key Researcher / Principal Investigator

Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (LBI-RUD)
Job Location
1090 Vienna
Job Description

Become a founding group leader at Austria’s Research Institute for Rare and Undiagnosed Diseases!

We are looking for outstanding biomedical scientists who would be eager to start or consolidate their research group at an exciting new institute pursuing basic and translational research on rare diseases, with a specific focus on genes and disease mechanisms relevant to hematopoiesis, the immune system and the nervous system.

More than 7,000 rare diseases affect up to 5% of the general population, constituting a major and largely unmet medical need. Moreover, rare and undiagnosed diseases offer unique opportunities to identify key genes and mechanisms underlying human physiology and diseases. Because the majority of rare diseases are caused by single-gene defects they facilitate clear mechanistic understanding of genotype-phenotype links relevant far beyond the individual disease under study, also enabling the development of personalized treatment strategies. Accordingly, rare and undiagnosed diseases are paradigmatic for the upcoming era of precision medicine, and LBI-RUD will broadly embrace their pioneering role for the future of medicine.

The institute has established a coordinated research program on the genetic and epigenetic origin and the functional basis of rare diseases, with a special focus on inborn errors of the immune system and the nervous system. Previous scientific publications by the LBI-RUD key researchers have enabled the identification of novel genetic defects underlying primary immunodeficiency disorders (e.g. Boztug K et al Nature Genet 2014, Willmann K et al Nature Commun 2014, Dobbs K et al New Engl J Med 2015), and monogenic neuronal diseases (Nagy V et al Cell Cycle 2015). The institute has first-hand access to the latest assays for high-throughput sequencing and single-cell profiling (Schmidl et al Nature Methods 2015, Bock et al Nature Biotechnol 2016). It also investigates the ethical and societal dimensions of rare diseases research. 

The Position

Initial appointments will be made for up to seven years with tenure option, and the successful candidate will be offered a competitive salary and research budget. Of the 4 key researchers at our institute, 2 hold a prestigious ERC Starting Grant by the European Research Council. The institute will provide support and mentoring to apply for additional external research funding at the Austrian and European level. LBI-RUD researchers are well-connected in global networks and will support young investigators in their effort to build up own new research collaborations in the field of rare and undiagnosed diseases.

How to Apply

Please submit a detailed CV including publication list, information on research interests and achievements, a short proposal of planned research, and contact details of 3 referees as a single PDF file to: with the reference code #PI/LBIRUD16 in the header. Please also provide your timeline or earliest/latest starting date, respectively. Application deadline is 15th July 2016, or until the position is filled. 

About Our Organization

The newly founded Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases is directed by Kaan Boztug, a world-leading expert in primary immunodeficiency research, and is situated in a beautiful, bright, and perfectly designed building with outstanding design and state-of-the-art laboratories and technology platforms that is strategically located next to one of the world’s largest university hospitals in the heart of the city. The institute holds close ties with its renowned partner institutions, namely the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, the Medical University of Vienna, and the Children’s Cancer Research Institute of the St. Anna Children’s Hospital, and is, therefore perfectly situated to benefit from strong translational research long established by leading-edge research groups.

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