An Investigator (Laboratory Head) position is available at the Novartis Institute of Biomedical Research in the field of oncology drug discovery in vivo pharmacology. We seek an experienced, motivated and ambitious scientist wishing to establish a successful scientific career in a drug discovery environment.
The position is based at the Novartis Institutes of BioMedical Research (www.nibr.com) in Cambridge, MA.
The successful candidate should have a strong background in cancer biology and immunology, with a proven ability to conduct multidisciplinary research in a competitive field and an excellent record of achievements. The ideal candidate will have solid expertise with in vivo cancer and immunology models and will have demonstrated experience with complex in vivo models adaptable to an immuno-oncology drug discovery environment. Prior drug discovery experience is preferred, but not required.
• Perform a key role in the establishment of novel rodent models for oncology drug discovery in the field of cancer and immuno-oncology.
•Lead a drug discovery pharmacology laboratory with direct reports and drive the scientific achievements through independent experimentation and data analysis. Assume responsibility for group's results, along with communication and presentation of such results at internal and external meetings.
• Contribute scientific and in vivo expertise to cross-functional projects. Drive the project decision-making process, conceptualize and drive research projects to completion.
• Engage in independent research that will lead to innovative findings and novel fundamental insights. This includes driving the development of novel efficacy and PK/PD relationships assessing both cancer cell and immune effector phenotypes.
• Support and contribute to departmental objectives supporting a diversity of therapeutic modalities through direct experimentation, as well as coaching and mentoring colleagues.
• Author, review and approve internal reports and presentations in addition to external publications and patent applications.
• Ph.D. degree in Immunology, Cancer Biology, Cancer Immunology or equivalent with post-doctoral training.
• Fluency in English (oral/written)
• A minimum of 3 years' experience post-doctoral training in a core scientific area, with a strong publication record. 0-3 years' experience in a drug discovery pharmacology setting is desired.
• Expertise with in vivo models required.
• Demonstrated expertise with various methodologies to characterize pharmacodynamics effect, including multi-color flow cytometric analysis of immune effector phenotypes.
• Excellent oral and written communication skills.
• Knowledge of various small animal imaging technologies or experience in pharmacokinetic modeling is a plus.
• The candidate should have the ability to flourish in dynamic, highly matrixed environments.
At NIBR we believe that along with our scientists, our culture is our greatest asset. To drive that culture each employee is expected to function in an innovative and collaborative manner. Each successful candidate will be able to demonstrate how they have functioned in this manner to drive results.