Experimental Officer (NMR Metabolomics)

Organization
University of Birmingham
Job Location
School of Biosciences
University of Birmingham, Edgbaston
Birmingham
West Midlands
B15 2TT
United Kingdom
Salary
£29,301 - £38,183, with potential progression once in post to £40,523 a year.
Job Description

To contribute significantly to the excellence of the NERC Biomolecular Analysis Facility – Birmingham (NBAF-B), the UK’s national research centre for Environmental Metabolomics. In particular to conduct NMR spectroscopy based metabolomics analysis and metabolite identification; to liaise with collaborating environmental scientists; to contribute to the Birmingham Metabolomics Training Centre; and to undertake independent research in NMR metabolomics. 

  • Conduct NMR based metabolomics experiments within NBAF-B, from experimental design, sample preparation, data collection using Bruker 600 MHz NMR spectrometers, through to processing of the NMR data (40%).
  • Conduct metabolite identification within NBAF-B primarily using solid phase extraction, liquid chromatography and multi-dimensional NMR spectroscopy using 600 and 800 MHz NMR spectrometers, including de novo structural identification of metabolites (30%).
  • Undertake some independent research in NMR metabolite analysis and/or metabolite identification that will help to widen the portfolio of metabolite analyses offered by NBAF-B or by Phenome Centre Birmingham (20%).
  • Provide training in NMR metabolomics specifically through the Birmingham Metabolomics Training Centre.
  • Assist visiting scientists with the analysis and interpretation of NMR metabolomics datasets.
  • Advise the NMR technical staff within the Phenome Centre Birmingham.
  • Contribute to the day-to-day operation of NBAF-B, including project design and troubleshooting, the prioritisation of data collection and analyses.

  • Disseminate research findings through contribution to peer-reviewed publications.
  • Present research findings at conferences in the form of talks/posters.
Requirements

• PhD or equivalent experience in NMR spectroscopy, NMR metabolomics, bioanalytical chemistry or natural products chemistry. 
• Significant hands-on experience in small molecule NMR spectroscopy, including spectral processing, interpretation and statistical analysis, including for the de novo identification of metabolites using multi-dimensional NMR spectroscopy. 
• Experience in the application of this technique to the analysis of complex biological mixtures. 
• Experience in metabolite identification. 
• Experience in conducting multiple projects simultaneously. 
• Excellent communication and interpersonal skills. 
• PhD or equivalent experience in NMR spectroscopy, NMR metabolomics, bioanalytical chemistry or natural products chemistry. 
• Significant hands-on experience in small molecule NMR spectroscopy, including spectral processing, interpretation and statistical analysis, including for the de novo identification of metabolites using multi-dimensional NMR spectroscopy. 
• Experience in the application of this technique to the analysis of complex biological mixtures. 
• Experience in metabolite identification. 
• Experience in conducting multiple projects simultaneously. 
• Excellent communication and interpersonal skills. 
• A high level of accuracy and attention to detail. 
• Ability to work on own initiative, manage time effectively, progress tasks concurrently and work to deadlines. 
• Detailed knowledge of laboratory safety. 
• Ability to assess resource requirements and use resources effectively.

How to Apply

Visit the UoB job section at the following link, download and review a full Job Description, and click "Apply Now".

https://atsv7.wcn.co.uk/search_engine/jobs.cgi?SID=amNvZGU9MTYyNDg4MiZ2d...

About Our Organization

The Metabolomics Initiative at the University of Birmingham began in earnest in 2003 and now encompasses several Schools including Biosciences; Geography, Earth & Environmental Sciences; Medicine; Mathematics and Computer Science. Our metabolomics research spans the development of analytical and bioinformatic methods as well as their application to wide ranging and numerous projects in the Life Sciences. These include studies in mammals, fish, invertebrates, microbes and plants, with a particular emphasis in both environmental metabolomics and clinical metabolomics. The bioanalytical facilities and expertise in both NMR spectroscopy and mass spectrometry at Birmingham are world class and include the Henry Wellcome Building for Biomolecular NMR Spectroscopy with four 600 MHz, one 800 MHz and one 900 MHz NMR spectrometers; Phenome Centre Birmingham with two 600 MHz Bruker NMR spectrometers and twelve Thermo and Waters LC-MS(/MS) for untargeted and targeted metabolite analyses; and the Advanced Mass Spectrometry Facility with Thermo Orbitrap Elite, Q Exactive and TSQ Vantage mass spectrometers (see below). The bioinformatic facilities and expertise at Birmingham include the new Centre for Computational Biology and several high performance computing clusters (details below). Our current and highly active research programme involves ca. 30 principal investigators, postdoctoral researchers and PhD students in metabolomics.

 

 

 

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