Ensembl Variation Project Leader

Job Location
Wellcome Genome Campus
CB10 1SD
United Kingdom

EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation. The remuneration package comprises a competitive salary, a comprehensive pension scheme and health insurance, educational and other family related benefits where applicable, as well as financial support for relocation and installation.

We have an informal culture, international working environment and excellent professional development opportunities but one of the really amazing things about us is the concentration of technical and scientific expertise – something you probably won’t find anywhere else.

If you’ve ever visited the campus you’ll have experienced first-hand our friendly, collegial and supportive atmosphere, set in the beautiful Cambridgeshire countryside. Our staff also enjoy excellent sports facilities including a gym, a free shuttle bus, an on-site nursery, cafés and restaurant and a library.

Job Description

Ensembl is one of the most internationally successful large-scale bioinformatics projects, and one of the leading projects for genome annotation. We are seeking a talented and motivated Project Leader to lead the variation data resources.

Large-scale sequencing projects are producing genome sequences in thousands more species, as well as deep sequencing in human to discover rare variants. These data have the potential to drive a better understanding of population genetics, evolution and genetic disease associations. Ensembl Variation processes massive amounts of data from various genomic archives and develops high quality annotation and analysis tools for variant interpretation, for example the Ensembl Variant Effect Predictor (VEP). The Ensembl Variation team is responsible for building variation databases for each Ensembl release, including development and maintenance of the variation MySQL databases and Perl APIs. This involves creating novel workflows and databases for integration of large heterogeneous datasets from all publicly available variation, phenotype and disease data; data exchange standards; novel visual displays and computational methods for accessing data. Future challenges will require exploring the use of new technologies and methods to scale to manage increasing volumes of data in greater numbers of species.

In this role your main responsibility will be to lead Ensembl Variation’s production and development projects. Typical tasks of the role will comprise:

  • Setting the direction and priorities for Ensembl Variation;
  • Meeting regularly with Ensembl Variation and the Variation Annotation Team Leader;
  • Managing development and production projects to completion;
  • Contributing to data produced for the Ensembl release cycles;
  • Providing scientific and technical guidance to Ensembl Variation;
  • Working with the Ensembl web developers and users to develop effective data displays;
  • Participating in the hiring and training staff;
  • Participating in the leadership of the Ensembl project;
  • Collaborating with international projects on and off campus;
  • Communicating the work to researchers in the field, including user support and training;
  • Preparing reports and presentations to represent Ensembl at internal and external meetings.

Applicants should have a first degree, PhD or higher qualification, in genetics or biological sciences. 

Candidates will need to demonstrate an in-depth understanding of bioinformatics, genetic variation and genomics. Extensive technical experience is key, including managing large datasets, data-mining, hands-on experience with relational databases, object-orientated Perl programming and familiarity with high throughput DNA sequencing data. Additional programming experience with the existing Ensembl code base, API and data analysis pipelines would be an advantage. Experience of hiring and managing a team, project management and working in a production environment is also important.

We are looking for highly motivated candidates with good communication and interpersonal skills. You will have scientific curiosity and initiative and enjoy working both independently and as part of a closely interacting team of international scientists. Skill in delivering a high quality product with excellent attention to detail and within fixed deadlines is essential.

How to Apply

To apply please submit a covering letter and CV through http://ig14.i-grasp.com//fe/tpl_embl01.asp?newms=jj&id=55168&aid=15470

About Our Organization

At EMBL-EBI, we help scientists realise the potential of ‘big data’ in biology by enabling them to exploit complex information to make discoveries that benefit mankind. Working for EMBL-EBI gives you an opportunity to apply your skills and energy for the greater good. As part of the European Molecular Biology Laboratory (EMBL), we are a non-profit, intergovernmental organisation funded by 22 member states and two associate member states and proud to be an equal-opportunity employer. We are located on the Wellcome Genome Campus near Cambridge in the UK, and our 600 staff are engineers, technicians, scientists and other professionals from all over the world.

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