We are seeking to recruit an enthusiastic software developer to join the Ensembl Regulation Team at the European Bioinformatics Institute (EMBL-EBI) located on the Wellcome Trust Genome Campus near Cambridge in the UK.
Ensembl Regulation is developing and maintaining a comprehensive map of gene expression regulation, focused on human and mouse. The team collects and processes public epigenomic datasets, such as histone marks, transcription factor binding, DNA methylation, or chromatin accessibility, and converts them into a functional annotation, highlighting features such as promoters, enhancers or insulators and keeping track of changes between cell types. The team also maintains an expressive API that allows users to conveniently query this high dimensional database.
The software developer will work on a Centre for Therapeutic Target Validation project which is jointly held between EMBL-EBI, the Wellcome Trust Sanger Institute and Glaxo Smith Kline. Their primary responsibilities will be:
• Processing most of the epigenomic datasets (-Chip-Seq, DNAsel hypersensitivity etc), produced by
the CTTV and integrating them into the Ensembl Regulatory Build, which is one of the most
comprehensive maps of regulatory elements in the human genome.
• Serve as the liaison between the Ensembl and CTTV projects and regularly report on their work and
scientific results to the different collaborators.
• Maintain and develop the codebase of the Ensembl Epigenomic Pipeline, and Ensembl in general, in
collaboration with the rest of the project developers.
EMBL-EBI is part of the European Molecular Biology Laboratory (EMBL) and is a world-leading bioinformatics centre providing biological data to the scientific community with expertise in data storage, analysis and representation. EMBL-EBI staff enjoy many benefits including sports facilities, a free shuttle bus to Cambridge and other nearby centres, and an attractive working environment set in 55 acres of parkland.