The Vertebrate Annotation team are looking to recruit a highly motivated bioinformatician to join the Ensembl Genebuild project at the European Bioinformatics Institute (EMBL-EBI).
Ensembl Genebuild produces gene annotation for vertebrate species, including the reference gene sets for human and mouse. We are one of the world’s leading groups for identifying the location, structure and tissue-specific expression of genes and their transcripts for large numbers of vertebrate species.
Your main responsibilities will involve running our large-scale annotation system to produce gene annotation. As part of Ensembl Genebuild, you will:
- Run production pipelines on a large compute cluster to download, process and integrate data from various public sequence archives
- Produce high-quality, evidence-based gene sets for vertebrate species including protein-coding genes, noncoding RNA genes and pseudogenes
- Produce tissue-specific RNA-seq alignments and transcript models
- Collate these data into appropriate databases and files for the Ensembl release cycle
- Document the data and processes used in gene annotation
- Contribute to the Ensembl code-base including the design and implementation of new annotation pipelines and software
- Work collaboratively with other members of Ensembl on data production around the Ensembl release cycles
- Communicate the team’s work internally and to researchers in the field, including user support
The Ensembl Genebuild project is a component of the Vertebrate Annotation team. As part of Ensembl Genebuild, you will join six bioinformaticians who are experts in gene annotation. We have domain area expertise in public archives, alignment methods, software development, large-scale compute, pipeline workflows and automation. Future projects for the team include: scaling up gene annotation pipelines, improving our annotation of noncoding genes, automating and enhancing our RNA-seq annotation pipeline, and developing methods of analysing new data including full-length transcriptomic reads.
This is a unique opportunity to contribute to Ensembl’s mission to analyse, store and disseminate genomic annotation. For further information about Ensembl, please visit: www.ensembl.org and www.github.com/Ensembl. For further information about Ensembl Genebuild, please visit: www.database.oxfordjournals.org.