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Engineer/ Sr. Engineer (Sequencing Operations)

Job Location
5500 Central Ave.
Boulder, CO 80301
United States

Inscripta offers a competitive base salary, bonus plan, benefits package and stock options to all team members.  Join us and work with a great team of people developing the world's first scalable platform for benchtop Digital Genome Engineering. Inscripta is headquartered in Boulder, CO with offices in Pleasanton and San Diego, CA.  This position is located in our Boulder headquarters.

Job Description

Inscripta is developing the world's first scalable platform for benchtop Digital Genome Engineering. The company’s advanced CRISPR-based platform, consisting of an instrument, reagents, and software, will offer a fully automated workflow that enables multiplexed, trackable editing of cells at an unprecedented scale. Inscripta’s goal is to empower scientists whose gene editing research is stifled by current technical and licensing limitations. By providing this unique platform and engaging in collaborative business practices, such as making its MAD7 CRISPR nuclease free for research purposes, the company enables scientists to realize a new era of biological discovery. 

Inscripta is looking for a driven, talented Engineer/Sr. Engineer who is interested in an exciting career growth opportunity within a company that is leading the next frontier of genome engineering. The Sequencing Operations Engineer will use proven engineering principles and best practices to develop products and processes, including implementation of process requirements and quality control practices, for procedures and instrumentation used in next generation sequencing. Working as a member of the Metrology team within Product Development, this engineer will partner with other engineers in R&D, Process Development, Operations and Quality in cross functional teams to enable new product introduction, process development, and process improvement.


  • Develop processes for verification and quality control of next generation sequencing library preparation methods and sequencer runs.
  • Support testing and translation of next generation sequencing methods with Biochemistry, Software and Automation teams.
  • Work with Software and Automation Engineers to test and scale up methods and processes for production.
  • Design, execute and report on controlled experiments to optimize process performance, improve and address reliability and quality issues, and drive implementation of robust procedures and solutions.
  • Analyze process test results, prepare standardized reports and make technical recommendations and improvements based on data.
  • Work cross-functionally with R&D, Manufacturing and Quality to develop requirements and performance indicators for next generation sequencing processes.
  • Write standard operating procedures for sequencing operations; maintain sequencing operations documentation.
  • Effectively organize and drive projects to achieve key milestones and deliverables on schedule, in matrixed, cross-functional teams.
  • Present clear and concise written and oral communication to product development, operations and senior management teams.

Required Educational Background and Work Experience:

  • B.S./M.S. in Chemical Engineering, Biochemical Engineering, Bioengineering, Biomedical Engineering, or similar engineering background.
  • 5+ years total commercial laboratory work experience with no less than 2 years of direct, hands-on experience with next generation sequencing library preparation, sequencer run QC and troubleshooting. Candidates with academic NGS/Genomics core facility experience will also be considered.

Required Skills and Experience:

  • Strong analytical problem solving and troubleshooting skills.
  • Strong working knowledge of statistics.
  • Demonstrated use of failure mode and effects analysis (FMEA) methodology.
  • Excellent interpersonal and communication skills, with the ability to interact with fellow team members and senior management.
  • Demonstrated expertise in standard molecular biological laboratory practices.
  • Must be goal-oriented and focused on completing work on time.
  • Must have ability to adapt to changing priorities and technical challenges in a fast-paced environment within an interdisciplinary team setting. 

Desired Skills and Experience:

  • Demonstrated expertise with automated fluid handling equipment (e.g. Tecan liquid handling robots).
  • Experience with use and user acceptance testing of laboratory information management systems (LIMS).
  • Experience with statistical process control (SPC).
  • Experience in at least one programming or scripting language such as R, Python, Matlab. 
About Our Organization

Inscripta is a gene editing technology company dedicated to creating the tools needed to revolutionize how we feed, fuel, and heal humanity. This includes developing a family of CRISPR enzymes (called MADzymes), bespoke nucleases for researchers and commercial partners, and a full suite of gene editing tools (software, instruments, and reagents) that will significantly increase the speed and efficiency of precision gene editing.

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