The Director of Network Modeling is a Science Director role within the CHDI Discovery Systems Biology Team, and will be a member of the Computational Modeling group within Systems Biology. The Director of Network Modeling will lead the development, integration and interpretation of Computational Models that represent the molecular networks and disease mechanisms underlying Huntington’s disease (HD) and in potential responses to treatment. Working both independently, and by coordinating the efforts of CHDI collaborators, s/he will interrogate these models to help define disease mechanisms, drug mechanisms of action, mechanisms of toxicity, and biomarkers that can be used clinically to follow these mechanisms in patients. The Director of Network Modeling will lead the development of new therapeutic strategies to intervene in disease processes. Working with the Discovery Systems Biology teams, s/he will interrogate these mechanisms to identify compensatory effects, in the furtherance of the development of actionable therapeutic strategies for treatment of HD. In addition, the Director of Network Modeling will work with CHDI Focus Area Teams to develop and interrogate models for these disease mechanisms, in order to facilitate the development and refinement of therapeutic strategies for the treatment of HD. This role is both a scientific management role, as well as an individual contributor role.
- Lead the integration and analysis of preclinical and clinical ‘omics data within the biological and disease context to enable the development of systems models for HD.
- Analyze, interpret and leverage of computational network models of biology (logical, causal, etc.) that describe aspects or the entirety of HD disease mechanisms
- Develop and lead collaborations with leading academic and commercial partners to further the development, integration, and interpretation of computational models of HD.
- Evaluate computational models to define potential therapeutic interventions for HD.
- Participate across CHDI’s Teams, providing direct support for the key objectives for programs.
- Contribute to the developing therapeutic strategies that will drive experimental interventions to support and advance drug discovery
- Identify appropriate models for testing therapeutic strategies, through comparative modeling
- Collaborate with leading pharmaceutical and academic scientists, working together to solve the biological challenges of Huntington’s disease.