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Director, Automation

Job Location
279 East Grand Aveune, 5th Floor
South San Francisco, CA 94080
United States

Medical, dental, vision, flexible PTO, 401K 

Job Description

Director of Automation 

As the Director of Automation at Freenome you will provide leadership to the automation team for the development high-throughput automation of complex assays for early cancer detection.  You will have an immediate impact on our current clinical trial, PREEMPT CRC, with 14,000 participants in the fight against the second deadliest cancer in the U.S., colorectal cancer.  You will also oversee the continued implementation of new and robust automated technologies into a regulated environment while working cross-functionally with the Clinical Lab, Development, and Quality teams

How you’ll contribute

  • Lead the automation development, optimization, and high-throughput scale-up of robust high-complexity assays (e.g., library preparation for next-generation sequencing) through platform and workcell automation
  • Build and manage an interdisciplinary team accountable to design, develop, test, validate, and integrate automated processes and workflows using liquid handling platforms
  • Collaborate cross-functionally to transfer technology and products from development into a regulated environment (CLIA/CAP/NYSDOH/FDA)
  • Lead and implement the vision and long-term roadmap for automated technologies at Freenome
  • Lead the evaluation and budgeting of new technologies, platforms, and systems that align with company priorities
  • Oversee the commissioning and maintenance of all automated systems, including creating maintenance, service, and qualification protocols with thorough and compliant documentation practices
  • Partner with other departments to improve assays and reduce COGs
  • Provide mentorship to team members by coaching and facilitating professional/personal growth opportunities


  • Ph.D. or relevant work experience in Mechanical Engineering, Molecular Biology, or related fields
  • 10 + years of experience developing and implementing automated laboratory processes in an FDA regulated environment
  • Biotech, Dx, IVD development experience required
  • Direct experience managing interdisciplinary teams
  • Experience working with liquid handling platforms and/or workcells, particularly with building automated methods on the Hamilton STAR platform for biofluids and nucleic acids in a regulated environment (CLIA/FDA)
  • Experience with laboratory information management systems (LIMS) integration and scheduling of automated platforms
  • Excellent problem solving and reasoning skills
  • Excellent written and oral communication skills
  • Demonstrated track record of high-throughput scale-up and optimization of systems


How to Apply

Highly qualified candidates who reside in the SF Bay Area or who want to relocate are encouraged to apply:


About Our Organization

About Freenome

Freenome is on a mission to empower everyone with the tools they need to detect, treat, and ultimately prevent diseases. 

By applying advanced machine learning techniques to recent breakthroughs in genomic science, Freenome is developing simple blood tests to detect early-stage cancer and make treatments more effective. The company has raised $238 million from investors such as RA Capital, Polaris Partners, Perceptive Advisors, Andreessen Horowitz, funds and accounts advised by T. Rowe Price Associates, Inc., GV (formerly Google Ventures), Roche Venture Fund, Kaiser Permanente Ventures, American Cancer Society’s BrightEdge Ventures, Data Collective Venture Capital, and Verily Life Sciences (formerly Google Life Sciences).

Our Science

Freenome is building technology to gain an understanding of the body through several analytes derived from blood. These signals include cell-free DNA, methylation of cell-free DNA, cell-free RNA, circulating proteins, and immune profiling derived from thousands of prospective samples. By developing novel statistical learning methods and applying them to integrate various -omics datasets, Freenome is a leader in modeling specific biological mechanisms to capture disease dependent signatures such as gene expression, immune response, tumor burden, the tissue of origin, and 3D chromatin structure. 

By building comprehensive discovery datasets and modeling critical biological systems, Freenome is learning what biological changes are present within the blood between a variety of different disease states including cancer, autoimmune disorders, infections, drug response, and aging. With the combination of Freenome’s datasets, cross-functional technical expertise, and mission to uncover the biological truth, we seek to positively change the lives of millions through the early detection and early treatment of disease.  

Our Culture

Freenomers are technical and creative, visionary and grounded, empathetic and passionate. We build teams around divergent expertise, which allows us to solve problems and uncover opportunities in unique ways. Freenomers are some of the most talented experts in their fields, coming together to advance healthcare one breakthrough at a time. 

We value empathy, integrity, and trust in one another. That means embracing other’s perspectives, those of our coworkers and those of the patients and communities we serve. It means knowing when to push, and when to listen. At Freenome, we give each other the benefit of the doubt in the belief that we’re all working as a team toward the same goals, and empower others to grow in a collaborative environment. 

What does a successful person look like at Freenome?

Those who thrive at Freenome prioritize, manage, and execute their own goals in alignment with those of the company. They embrace our values of empathy, integrity, and trust, and hold themselves and their team accountable. They crave collaboration with brilliant minds from unfamiliar fields of study and believe that hiring and mentorship are fundamental to our success. Above all, they welcome and provide constructive feedback and criticism, trusting in the good intentions of others, and secure in the knowledge that embracing mistakes is the best way to learn and move on. For those who crave challenges, understudied problems, and the chance to see their work impact the lives of millions of people affected by cancer every year, there’s no better place to be. 

Freenome is proud to be an equal opportunity employer and we value diversity. Freenome does not discriminate on the basis of race, religion, color, sex, gender identity, sexual orientation, age, non-disqualifying physical or mental disability, national origin, veteran status or any other basis covered by appropriate law. 

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