Pacific Biosciences is looking for a scientist to help improve the performance of its sequencing consumables. The successful candidate will work within a highly multidisciplinary R&D environment to develop data analysis methods and tools for extracting content from large single molecule sequencing data sets with the overall goal of improving the accuracy and readlength of mutant/engineered DNA/RNA polymerases and fluorescently labeled nucleotide analogs. Other areas of focus will be to improve nucleic acid sample preparation and subsequent sequencing performance as it pertains to polymerase processivity, DNA/RNA integrity, and secondary structure. Ideally, the candidate will have a strong background in data analysis techniques applied to challenging biophysical questions. A good working knowledge of biochemistry and/or bioinformatics is highly desirable.