Computational/bioinformatics research associate

Organization
Allcyte GmbH
Job Location
Lazarettgasse 14 AKH BT25.3
1090 Vienna
Austria
Job Description

Allcyte, a seed-phase biotechnology startup of the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences located in Vienna, Austria, is working at the forefront of functional drug profiling. Leveraging our Pharmacoscopy® high-content imaging platform, we develop in vitro diagnostic tests for personalized cancer therapy, as well as streamline drug development in oncology and immunology/immuno- oncology.

We are looking for a highly motivated computational research associate to take responsibility for the analysis of Pharmacoscopy imaging functional data, genetics, and other data-sets with the aim to gain a systems-level understanding of drug effect in cancer and immunity. Pharmacoscopy is an automated microscopy platform that is uniquely compatible with primary patient samples, and can measure both direct drug effects as well as immunomodulatory properties of drugs with single cell resolution. The work has been directly translatable at the academic level through an existing clinical trial (NCT03096821) for the prediction of clinical drug response in hematological cancers, and is outlined in various articles (Vladimer et al Nature Chemical Biology 2017 (summarized by Derek Lowe’s ‘In The Pipeline’), Snijder et al in review at Lancet Hematology, as well as others). 

The candidate should have excellent analytical skills, a strong interest in big data medicine, and a degree (MS/PhD) either in computational science/engineering or biology. The candidate will be required to adapt and expertly use existing bioinformatics tools, as well as develop data analysis protocols/pipelines for large image- based drug profiling campaigns and their integration with diverse –omics datasets. Strong statistical and script programming skills/experience (e.g. R - bioconductor, python, MATLAB), good command of the English language, and good interpersonal skills are a must. Experiences in artificial intelligence, computational image analysis, and advanced data visualization techniques are a bonus. The candidate will work closely with a software engineer. 

Allcyte’s high-content screening technology is changing the way that drugs and other soluble factors are functionally assayed through the robust quantification of visible phenotypes, all at the single cell level. The technology has gained traction in generating functionally significant and clinically relevant data for the stratification of treatments for patients with hematological malignancies, and the assessment of pre-clinical and clinical entities for their action on the immune system. 

The successful applicant will join a highly dynamic and interdisciplinary team at Allcyte in Q4 2017. He or she will have the unique opportunity to grow with the company both professionally and scientifically, including receiving milestone based incentives that are in line with company milestone and goals, while working to pioneer innovative therapeutic and diagnostic initiatives in cancer and immunity. Vienna is a budding biotechnology hub in the heart of Europe and was voted the city with the highest quality of life in the world by Mercer for eight consecutive years. 

 

The candidate will be responsible for the following: 

• Analyze and integrate patient-related high content imaging and sequencing data 

• Custom analysis of individual experiments, but also software development for routine use 

• The work will have a cloud computing and potentially a machine learning dimension 

The candidate should have the following Skills / qualities we are looking for:

• Experience in bioinformatics, statistics, machine learning, or mathematics 

• Strong statistical programming skills are a must 

• Dynamic, fast learning, analytical

• Highly motivated team player capable of independently driving a project

• Experience in computational image analysis, machine learning, advanced data analysis or database programming is beneficial

 

About Our Organization

Allcyte GmbH

Allcyte was founded by a highly collaborative team of 4 scientists from 4 nations who met in Vienna, Austria at CeMM, the Center for Molecular Medicine, and have built the company and the technology from the ground up, where it has entered routine clinical use in an academic environment. The technology has initiated many translational and high impact research projects and grants focused around immunology and hematology. The members of the founding team, one of whom will take the role as a senior scientist as Allcyte, have papers in Nature, Cell, Immunity, Nature Chemical Biology, Nature Biotechnology, Molecular Systems Biology, as well as other high impact journals, and are at the forefront of their fields. One of the co-founders, Prof. Giulio Superti- Furga is a serial entrepreneur (has co-founded Cellzome and Haplogen previously), is an ERC scientific council member, and holds many other key memberships and prestigious scientific awards. Allcyte is backed by government funding and private investments. You will enjoy a supportive mentoring from the group and profit from entering a budding start-up company at the beginning. www.allcyte.com

 

Allcyte's Founding Institute

CeMM is a flagship institute for biomedical research in the heart of Europe, Vienna. CeMM is committed to highest scientific standards as exemplified by recent publications in top journals as well as by its top international scientific advisory board. The environment is very collaborative, dynamic and international. One of CeMM's advantages is to be in close proximity to the Vienna Medical University Campus and the General Hospital (AKH). The Department of Hematology of the Medical University of Vienna has played a large part in the success thus far of Allcyte and our long-term relationship through strategic research collaborations will benefit both parties. This allows the fruitful interaction of basic scientists with clinicians, and the use of models and cutting-edge technology to disease-relevant biological questions. According to a study by The Scientist, CeMM is ranked as the best European place to work in Academia 2012, internationally CeMM appears at the fourth place. For more information please visit: www.cemm.at

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