Computational Scientist

Organization
Aduro Biotech
Job Location
740 Heinz Ave.
Berkeley, CA 94710
Job Description

Reports Into: Director, Immune Monitoring / Biomarker DevelopmentSummary/Objective

This position has primary responsibility for providing statistical and analytical bioinformatics expertise and interpretation to the scientific research programs at Aduro Biotech.

Responsibilities

  • Analyze large-scale datasets such as raw microarray data (miRNA and mRNA), genomic and RNA sequence data, cytometry and proteomics data for clinical or basic research purposes.
  • Perform integrative analyses of different data types including genomic, molecular, cellular, proteomics and clinical.
  • Consult with researchers to analyze problems, recommend technology-based solutions, or determine computational strategies.
  • Manipulate publicly accessible, commercial, or proprietary genomic, proteomic, or post-genomic databases.
  • Compile data for use in activities such as gene expression profiling and cell-type gene expression deconvolution bioinformatics.
  • Create novel computational approaches and analytical tools as required by research goals.
  • Create or modify web-based bioinformatics tools.
  • Design and apply bioinformatics algorithms including unsupervised and supervised machine learning, dynamic programming, or graphic algorithms.
  • Develop data models and databases.
  • Develop or evaluate new software applications or customize existing applications to meet specific scientific project needs.
  • Improve user interfaces to bioinformatics software and databases.
  • Instruct others in the selection and use of bioinformatics tools.
  • Provide statistical and computational tools for biologically based activities such as genetic analysis, measurement of gene expression, and gene function determination.
  • Keep abreast of new algorithms, technologies  or softwares by reading scientific literature and attending professional conferences.
  • Communicate research results through conference presentations, scientific publications, or project reports.
Requirements

Requirements/Qualifications

  • PhD degree in Statistics, Biostatistics, Computer Science or Bioinformatics, and 5 years relevant experience.
  • Experience in next-generation sequencing (NGS) data analysis, microarray data analysis (miRNA and mRNA), experimental design, data integration, algorithm development, development of sequence analysis tools (bioinformatics programming), evaluation of analytical tools and technology.
  • Experience in statistical packages (e.g. R/SAS) and other commonly used visualization and pathway analysis software packages such as DAVID, CytoSCAPE and Ingenuity Pathway Analysis (IPA) analytics.
  • Experience in developing computational algorithms and systems to support clinical research including proteomics, transcriptomics, metabolomics, and clinical bioinformatics and analyses.
  • Demonstrate the ability to interrogate large data sets and address biological hypotheses.
  • Strong programming and software engineering skills are required for this position including competence in Python,  R and database query language (ie MySQL) .
  • Bioinformatics expertise in biomedical research such as cancer biology, stem cell biology and immunology would be highly desirable.
  • A proven track record of “omics” data analysis, independent collaborative work and leading contributions to a biological discipline is preferred.
  • Enthusiasm for working in a dynamic high performance research team environment. 
  • Creative contributor eager to learn new technologies and science.
  • Excellent communication skills including skills necessary to present at the conferences and workshops, write study designs, analytical methods and analysis results.
  • Strong communication and interpersonal skills with both  computational and bench scientists are essential for success in this collaborative role


Aduro Biotech, Inc. is at the forefront of discovery, development and commercialization of breakthrough immunotherapies. We provide a workplace where employees excel, thrive and deliver value to patients, their families and our partners. Aduro headquarter office is located in Berkeley, California and international office located in Oss, The Netherlands.

Aduro Biotech, Inc. is an Equal Opportunity Employer

How to Apply

Aduro Biotech, Inc. offers a competitive salary and benefits package. Qualified candidates should forward a resume and cover letter including a statement of interest, availability, and experience in Word or PDF format to: [email protected]  PLEASE, NO PHONE CALLS.

About Our Organization

Aduro is dedicated to its mission to discover, develop, and commercialize immunotherapies that transform the treatment of challenging diseases, including cancer. To fulfill its mission, the company is advancing several leading-edge proprietary technologies that are designed to initiate and sustain the immune system to mobilize and attack tumors. Collectively, Aduro’s three technology platforms are uniquely positioned to recruit and direct the immune system by activating cancer-fighting immune cells and inhibiting immune suppressive cells known to allow tumor growth.

Product candidates from Aduro’s LADD (live, attenuated double-deleted Listeria monocytogenes), STING Pathway Activators, and B-select monoclonal antibody platforms are designed to stimulate and/or regulate innate and adaptive immune responses, either as single agents or in combination with conventional therapies (chemotherapy and radiation) as well as other cutting-edge immunotherapies. This diverse set of technology platforms has led to a strong pipeline of clinical and preclinical candidates, which are being evaluated in a number of cancer indications. Additionally, Aduro’s platforms have the potential to generate product candidates that address other therapeutic areas, such as autoimmune and infectious diseases.

Aduro collaborates and partners with leading academic investigators, along with pharmaceutical and biotechnology companies in an effort to develop its technologies in an expeditious manner and make new therapies available to patients in need.

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