Computational Post-Doctoral Position at Cold Spring Harbor Laboratory

Cold Spring Harbor Laboratory
Job Location
1 Bungtown Road
Cold Spring Harbor, NY 11724

Comprehensive postdoc benefits

Job Description

Computational Post-Doctoral Position at Cold Spring Harbor Laboratory.

Cold Spring Harbor Laboratory invites applications for a joint post-doctoral position in the laboratories of Gholson Lyon & Jesse Gillis. The focus will be on developing computational methods to understand the basis of a highly targeted disease, TAF1 syndrome. The Lyon lab recently published the discovery of this X-linked syndrome associated with sequence variants in TAF1. Its cardinal features include dystonia, intellectual disability, and other dysmophologies.

Our group currently has access to the largest known TAF1 Syndrome cohort and mutation database in the world. As such, we are uniquely positioned to perform a robust set of experiments that fully capture the TAF1 Syndrome phenotype and its molecular etiology, which can reveal how TAF1 is contributing to disease phenotypes. While our focus is on TAF1, the application of methods developed may be far broader as the interpretation of rare human variation remains a critical and unsolved problem.

The successful candidate will join an interdisciplinary team at the Stanley Institute for Cognitive Genomics at CSHL working to understand the molecular basis of TAF1 syndrome. The expected duration of the position is 2 years with renewal at the end of each year and the possibility of extension, depending on the success of the project.

A broad range of computational backgrounds are suitable for this position.


A broad range of backgrounds are suitable for this position, although experience in bioinformatics or computational biology is preferred and a Ph.D. is required; preferably a candidate near graduation or has graduated within the past year. Exceptional applicants without a formal computational background will also be considered, particularly if they are familiar with standard bioinformatics tools. Familiarity with either Matlab or R is a plus.

If interested, please apply for this position via the CSHL careers website at:

Position Number: 01441-R

Please include a letter of interest outlining your research accomplishments and include the contact information of three references.


For more information about CSHL, please visit us at

CSHL is an EO/AA Employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability or protected veteran status.

VEVRAA Federal Contractor

How to Apply

If interested, please apply for this position via the CSHL careers website at:

Position Number: 01441-R

About Our Organization

Cold Spring Harbor Laboratory is a world-renowned research and educational institution with programs in cancer, neuroscience, plant biology, genomics and bioinformatics. The Laboratory is recognized internationally for its excellence in research and educational activities.

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