Computational Biologist/Bioinformatician, PMCC-OICR Translational Genomics Laboratory

Organization
OICR
Job Location
661 University Avenue
Toronto, ON M5G0A3
Canada
Benefits

HOOP pension plus other benefits. 

Job Description

The Ontario Institute for Cancer Research (OICR) is seeking a Computational Biologist/ Bioinformatician to join the Translational Genomics Laboratory (TGL); a partnership between Princess Margaret Cancer Centre and OICR. The TGL forms a critical link between active/live clinical trial cohorts hosted within Ontario and strengthens clinician access to in-depth, research level, multi-omic analysis. The incumbent will be immersed within OICR’s Informatics and Biocomputing division with access to OICR’s 5600+ core HPC computing environment.  As part of a growing team, the individual will join a collaborative work environment with a focus on clinically related TGL research initiatives leveraging genomics technologies.

The candidate is expected to:

  • Develop a web-based computational approach to large-scale interpretation of genomic variants 
  • Create novel visualization methods to depict data in support of clinical reporting
  • Enable high-level browsing of clinical and genomic datasets (Exome, RNA-Seq, Methyl-Seq & EPIC methyl array) generated by TGL and its collaborators for clinicians and researchers
  • Setup and host a local server for operation of cBioPortal (http://www.cbioportal.org/) to warehouse and visualize such data
  • Develop programmatic approaches to link genomic and clinical databases as part of the above activities
  • Improve existing applications with new features and enhancements
  • Deploy applications for production as required
  • Build APIs and web services that link our systems together and facilitate reporting
  • Be responsible for documenting and communicating pipeline processes and building the team knowledge base
  • Responsible for researching, planning, implementing, and testing bioinformatics software tools that meet the analysis needs for TGL
Requirements
  • Completion of a MSc, PhD or equivalent experience  in computer science or computational biology
  • Experience in some or all of the following fields: clinical genomics, oncology, knowledge-based systems, web and information science
  • High proficiency in multiple computer systems & packages for database development, coding, statistics, visual design, etcetera
  • Must have advanced skills in Unix shell programming environment
  • Proficiency with Unix based scripting language (Perl, Python, etcetera)
  • Strong competence in Java (or similar languages)
  • Experience with Illumina data beneficial
  • Understanding of requirements for software used in a regulated/clinical lab environment beneficial
  • Ability to work under pressure, collaboratively, and perform multiple concurrent and/or prioritized tasks while maintaining attention to detail
  • Excellent organizational skills including written and verbal communication
About Our Organization

OICR is an innovative cancer research institute located in the MaRS Centre in the Discovery District in downtown Toronto. OICR is addressing significant challenges in cancer research with multi-disciplinary, multi-institutional teams. New discoveries to prevent, detect and treat cancer will be moved from the bench to practical applications in patients. The OICR team is growing quickly. We are innovative, dedicated professionals who bring expertise to each of our roles. We are looking for individuals interested in being part of a culture of excellence that will result in Ontario being recognized internationally as a leading jurisdiction for cancer research.

Launched in December 2005, OICR is an independent institute funded by the Government of Ontario through the Ministry of Research and Innovation.

 For more information about OICR, please visit the website at www.oicr.on.ca.

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