Computational Biologist

Broad Institute
Job Location
Cambridge, MA
Job Description

We are looking for a highly motivated individual to join the Stanley Center for Psychiatric Research at the Broad Institute. The Stanley Center is working to identify the cellular and molecular pathways disrupted in brain disorders such as schizophrenia and bipolar disorder, by developing and applying assays and tools to understand how implicated genes act in neurons and circuits. This person will develop new computational methods, apply existing methods, interpret results with a biological context, and refine techniques and metrics appropriate for these analysis pipelines.

The candidate will collaborate with laboratory scientists to develop new laboratory methods and must enable the research of these scientists through excellent communication, teamwork, and a focus on creating usable and accessible research software tools. The candidate will work with the Stanley Center’s Assay Development, Neurobiology and Genome Engineering teams. The candidate should have a strong background in mathematics or statistical genetics, have fluency with biology and/or neuroscience, and be able to adapt quickly and be part of a cross-functional team in a rapidly changing environment.

The Stanley Center and the Broad Institute provide a vibrant research environment with close links to MIT, Harvard and the Harvard-affiliated hospitals across Boston. Being a member of our team will provide the opportunity for your contributions to be utilized and recognized across the vast global network of researchers in the fields of genomics and psychiatric disease research.

- Develop, apply, document, and maintain computational tools, both for own use and to support analysis by biologist colleagues without formal computational training. Critically evaluate computational solutions, finding and addressing failure modes on one’s own.
- Develop customized computational solutions supporting new kinds of assays and experiments. Understand the analytical needs of new experiments, working closely with biologists and chemists.
- Follow relevant scientific literature to ensure use of optimal methods and understand emerging practices across the field.
- Implement and optimize successful algorithms and methods for use by the broader community.
- Contribute to reports and papers for presentation and publication. Present at scientific conferences, as needed.
- Develop figures and reports, which provide transparency into the data quality and characteristics, and automate the production of such reports.
- Help implement analysis methodologies into software tools for publication and distribution to the psychiatric disease research community.
- Attend lab and project team meetings on a semi-regular basis to ensure continuous communication around methods and tools developed.
- Ph.D. in computer science, engineering, physics, mathematics, biology, or related fields.
- Demonstrated experience designing computational methods and tools, including prior experience with algorithms relevant to computational biology, and skill and experience with statistical analysis is strongly preferred
- Must have demonstrated proficiency with several of the following technologies: Perl, Python, Java, Matlab, R, C, C++, Unix
- Basic understanding of molecular biology
- Excellent communication and interpersonal skills.
- Ability to work independently while making the necessary connections with experts in various computational analysis groups .
- Excellent written and oral presentation skills.
- Excellent organization and time management skills.
- Must be flexible and able to respond to shifting priorities in a dynamic setting.

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