Computational Associate II

Broad Institute
Job Location
Cambridge, MA
Job Description

We are searching to fill an associate computational biologist position for the Malaria Genome Sequencing and Analysis group at the Broad Institute. The person filling this position will assist in performing bioinformatic analyses on genomic and transcriptomic data from infected blood samples. She or he will work collaboratively with other bioinformatic scientists as well as wet lab biologists to interpret data and make it accessible to a large interdisciplinary group.

The scope of activities may range from generating analysis pipelines that will be used many times to carrying out one-off analyses to ask a specific question of a particular dataset. The broader goals of the work will be to develop differential genomic and transcriptomic diagnostic markers of malaria and other co-morbid infectious diseases affecting the developing world, to better understand the biology, evolution, and transmission of malaria parasites, and to determine how genomic diversity contributes to drug-resistance, immune evasion, and other etiologies in malaria.

- Perform bioinformatic analyses to extract biological meaning from next-generation sequencing, genotyping and RNA-seq transcription data
- Research and identify proper approaches for interrogating data using primary literature
- Work collaboratively with wet lab scientists at the Broad as well as other institutions to make data accessible and interpretable
- Learn, utilize, and extend existing tools and pipelines for data analysis within the group
- Submit large datasets to public archives
- Perform other duties as necessitated by the position or as assigned

- B.S. degree in computer science, bioinformatics, biological sciences, or related field required, M.S. degree strongly desired.

Proficiency in:
- R statistical programming language
- Unix
- Scripting languages such as Perl or Python

Working knowledge of:
- Basic sequence analysis tools (BLAST, alignment, etc.)
- Other statistical tools (Matlab, etc.)
- Next generation sequence data analysis tools (BWA, samtools, GATK, etc.)
- RNAseq analysis and visualization tools (Tuxedo Tools, Trinity, etc.)
- Bioinformatics tools (Cufflinks, GenePattern, IGV, GENE-E)
- Relational databases

General abilities required: Must be able to run traceable and reproducible analyses. Must have an aptitude for data display and interpretation. Must be able to multi-task, work independently and collaboratively, adapt to changing priorities, and work in face-paced environment. Strong verbal, written, and presentation communication skills are essential.

The Broad Institute will not offer visa sponsorship for this opportunity.

EOE/Minorities/Females/Protected Veterans/Disabilities

If interested, please apply online at

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