Clinical Genomics Associate (Diagnostic Test Development)

Organization
Partners HealthCare Personalized Medicine
Job Location
Cambridge, MA 02139
Benefits

Competitive Benefits

Job Description

The Harvard Medical School affiliated Laboratory for Molecular Medicine (LMM) is a CLIA-certified molecular diagnostic laboratory operating within Partners Personalized Medicine. The mission of the LMM is to bridge the gap between research and clinical medicine by translating novel discoveries into cutting-edge tests and accelerating the adoption of new molecular tests into clinical care. 

The successful candidate will work in a cutting edge environment in the Diagnostic Test Development group. This will entail design, optimization, and clinical validation of molecular diagnostic tests for inherited disorders with genetic and clinical heterogeneity. There is a strong focus on clinical next generation sequencing technologies. Academic activities including presentations and publications are strongly encouraged but not required.

This position is ideal for a post doctoral candidate, preferably with a background in genetics, who is interested in a career in clinical genomics and molecular diagnostics. Computational and/or bioinformatic skills are a plus.

The successful candidate is expected to work independently with minimal supervision. 

Major responsibilities include:

  • Evaluation of novel platforms and techniques in DNA sequencing, genotyping, and copy-number variation in order to assess suitability for diagnostic application.
  • Design and execution of clinical validation studies to determine the diagnostic performance of genetictests.
  • Analysis of large datasets in collaboration with the Center's bioinformatic staff.
  • Documentation of clinical test development according to regulatory guidelines.
  • Interfacing with the clinical operations team to launch novel assays.
  • Help train operations staff to perform novel assays.
  • Quality improvement (optimization) of existing genetic tests.
  • Conference attendance and presentations are a possibility.
  • Publications are encouraged.
Requirements
  • Advanced degree (PhD or equivalent) in molecular biology, human genetics or related field preferred.
  • MS degree may be considered depending on level of relevant experience
  • Solid experience with standard molecular genetics technologies, ideally including Next Generation sequencing
  • Statistical and bioinformatics skills are a plus
How to Apply

Please send a cover letter and resume to Amy McGlinn (amcglinn@partners.org).

About Our Organization

Partners HealthCare Personalized Medicine (formerly known as the Partners HealthCare Center for Personalized Genetic Medicine or PCPGM) is a division of Partners HealthCare, an integrated health care system founded by Brigham and Women’s and Massachusetts General Hospital, both Harvard-affiliated teaching hospitals, and the largest independent hospital recipients of National Institute of Health (NIH) research funding in the United States. 

Partners Personalized Medicine was founded in 2001 by Partners HealthCare and Harvard Medical School (HMS) as the Harvard-Partners Center for Genetics and Genomics. The center was launched before completion of the Human Genome Project as an early commitment to, and in recognition of, the potential for genomic knowledge to dramatically improve health care.  This mission, to better understand and harness the unique genetic and genomic makeup of individuals to improve their health, continues today.

As a part of the Partners HealthCare system, and through its affiliation with Harvard Medical School, Partners Personalized Medicine is uniquely positioned to leverage the talent and resources of Partners HealthCare system and impact the research and clinical activities of one of the largest and most transformative health care systems in the country

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