Chemogenomics Analyst

Organization
EMBL-EBI
Job Location
Wellcome Trust Genome Campus Hinxton Cambridge
Hinxton
CB10 1SD
United Kingdom
Benefits

EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation. The remuneration package comprises a competitive salary, a comprehensive pension scheme and health insurance, educational and other family related benefits where applicable, as well as financial support for relocation and installation.

We have an informal culture, international working environment and excellent professional development opportunities but one of the really amazing things about us is the concentration of technical and scientific expertise – something you probably won’t find anywhere else.

If you’ve ever visited the campus you’ll have experienced first-hand our friendly, collegial and supportive atmosphere, set in the beautiful Cambridgeshire countryside. Our staff also enjoy excellent sports facilities including a gym, a free shuttle bus, an on-site nursery, cafés and restaurant and a library.

Job Description

We are looking to recruit a scientist to support our work for the Horizon 2020 project “Coordinated Research Infrastructures Building Enduring Life-science services” (Corbel). The role is to work directly with scientists from around Europe in their use of our chemogenomics resources (particularly ChEMBL), to progress their research projects and to develop training programmes.

Function and Responsibilities

  • To be responsible for liaising with scientists engaged in Corbel and advising on the use of chemogenomics resources to progress their projects
  • To organize and run appropriate training courses for scientists engaged in the Corbel project
  • To help in the identification and analysis of bioactivity data from multiple database resources
  • To construct and utilize appropriate workflows to facilitate the pharmacological profiling of molecules and chemotypes, the identification of potential off-target effects and the development of target prediction models.
  • To identify interoperability gaps between resources and help with developing solutions


The appointee will report to the ChEMBL Group Leader.

Requirements

You will have a PhD (or equivalent) in a chemical, biological or biomedical science. They will also have sound knowledge of chemoinformatics, pharmacology and mechanisms of drug action.

You are likely to have postgraduate experience of working in a research environment on multi-disciplinary projects. Prior experience of data analysis and working with chemical structures and bioactivity data is essential. You will also have a good understanding of the components of the drug discovery process. Some previous experience in training and/or working with collaborators is desirable.

The appointee will be competent in a programming/scripting language such as python, Perl etc. Preferably, they will have experience of working with chemoinformatics toolkits such as RDkit. Experience working with workflow tools such as knime or pipeline pilot is also desirable. Experience with statistical analysis software and the ability to query relational databases using SQL would also be advantageous.

The successful candidate will work closely with members of the ChEMBL Group as well as scientists from other institutions working on the Corbel project. The candidate will therefore need to be a team player, engaging with multiple collaborators and be able to independently identify innovative solutions to diverse drug discovery questions. You will have excellent communication skills (both verbal and presentational).

How to Apply

To apply please submit a covering letter and CV, with two referees, through our online system

About Our Organization

At EMBL-EBI, we help scientists realise the potential of ‘big data’ in biology by enabling them to exploit complex information to make discoveries that benefit mankind. Working for EMBL-EBI gives you an opportunity to apply your skills and energy for the greater good. As part of the European Molecular Biology Laboratory (EMBL), we are a non-profit, intergovernmental organisation funded by 22 member states and two associate member states and proud to be an equal-opportunity employer. We are located on the Wellcome Genome Campus near Cambridge in the UK, and our 600 staff are engineers, technicians, scientists and other professionals from all over the world.

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