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Biotechnology Platform Manager

Organization
DNA Script
Job Location
67 avenue de Fontainebleau
94270 Le Kremlin-Bicêtre
France
Job Description

Biotechnology platform manager/Biotechnology Automation Scientist

The role

DNA Script is looking for a talented individualto take up a key role within the Applications team. He or she will be in charge of developing and managing the Assembly platform dedicated to produce nucleic acid assemblies based on the company’s enzymatic technology to manufacture de novo synthetic nucleic acids and novel assembly techniques. This platform will play a central role for DNA Script by demonstrating the ability of Syntax and EDS technology to provide oligonucleotidesthat can be used to produce any targeted synthetic gene.

The candidate will be in charge of implementing the full process of synthetic gene/nucleic acid assembly, from the reception of orders, oligonucleotide design, assembly production, sequencing analysis, QC and customer delivery. He or she will implement the specific assembly strategy defined by the R&D Assembly principal scientists in a given project. In addition, the candidate will be responsible of transferring the protocols developed by the R&D Assembly scientists in the Applications team and adapt them to the Assembly platform in a robust automated way.

To perform these tasks, the candidate will need to interact with many different teams, in particular the R&D Assembly scientists in the Applications team that will develop the assembly protocols and define the assembly strategy for a given project, the Bioinformatics team that will provide the oligonucleotide designs and perform analytics, the Synthesis platform that will produce the starting oligonucleotides and the NGS platform that will analyse the assembled sequences. He or she will be assisted by a technician.

We are seeking an individual who is well organized, proactive, detail-orientated, enjoys problem-solving, and is able to work in a multi-disciplinary role.

Responsibilities

  • Develop and manage an automated Assembly Platform: Ensure efficient and reproducible day to day operations, provide high quality results, ensure high equipment uptime, manage team and resources (equipment, reagents, consumables), 

  • Work collaboratively with groups across the company to set up appropriate projects

  • Perform in-depth analysis of experimental data, 

  • Effectively document and report on platform KPI, QC data and processes,

  • Engage in good laboratory/documentation practices, write Standard Operation Protocols (SOPs) and enforce their correct use,

  • Actively contribute towards critical company milestones, with a willingness to work outside immediate area of expertise where required.

Requirements

Qualifications and experience

Essential

  • Process or biotechnology engineering, PhD or similar,

  • Minimum of five years’ experience in managing a service platform, preferentially in the field of molecular biology, 

  • Experience in molecular biology methods including PCR, restriction digestion, DNA/RNA purification, and nucleic acid characterisation and/ or in nucleic acid synthesis.

  • Experience in automation, liquid handlers, high throughput screening or analysis, 

  • Excellent knowledge of Excel and other Microsoft Tools, 

  • Excellent organisational, analytical, and systematic troubleshooting skills,

  • Excellent communication and interpersonal skills, 

  • Highly motivated, with a passion for developing tools and methods, 

  • Ability to work independently and as part of a large multi-disciplinary team,

  • Dynamic with positive attitude willing to engage at a very high level, 

  • Excellent English language level as well as at least an intermediate French language level.  

Desirable 

  • Experience in following or implementing quality systems such as ISO 9001 or ISO 13485.

  • Experience in coding with Visual Basic Script (VBS), python or the like. 

  • Knowledge on gene assembly protocols

How to Apply
About Our Organization

DNA Script is a leading company in manufacturing de novo synthetic nucleic acids using a proprietary enzymatic technology. DNA Script’s approach leverages nature’s billions of years of evolution in synthesizing DNA to set a new standard for how nucleic acids are made and accelerate the adoption of synthetic biology across diverse disciplines such as biopharma, sustainable chemistry and data storage. DNA Script’s first product will be a DNA printer. On course to hit the shelves in 2021, this benchtop instrument will enable researchers to target and program specific areas of the genome.

To date, DNA Script has raised over $100M of financing, mostly through leading investors such Casdin, Agilent, Danaher, LSP, Bpifrance, Illumina Ventures, Merck Ventures, Sofinnova Partners, Kurma Partners, Idinvest.

DNA Script has its research facility headquartered in Paris, France, and is in the process of expanding its commercial and development teams in South San Francisco.

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