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Bioinformatics Scientist, Clinical Cancer Genomics

New York Genome Center
Job Location
101 Avenue of the Americas
New York, NY 10013
United States
Job Description

Position Description

The New York Genome Center is looking for a highly motivated, detail-oriented individual to join our rapidly expanding Clinical Informatics division within the NYGC CLIA Laboratory. As a Bioinformatics Scientist specializing in molecular diagnostics, you will be responsible for the handling of custom analysis and reporting of next-generation sequencing (NGS) data for cancer, conformant to CLIA / CLEP guidelines. You will work as part of a team of highly experienced laboratory staff, informatics scientists and analysts at the NYGC CLIA Laboratory. You will be asked to perform variant calling analysis from whole genome, whole exome and transcriptome patient sample sequencing data. You will be part of a team of CLIA scientists and laboratory personnel taking an active part in generating, developing and reporting patient sample genomic profile reports. You will assist clinical informatics and laboratory scientists in developing and validating new NGS based clinical laboratory tests You should have significant experience in cancer genomics, including familiarity with commonly used algorithms for alignment, variant calling, structural variant calling and clinical biomarker identification. Expertise in one or more common disease areas would be ideal with specific focus on cancer and therapeutic mechanisms. You will use your experience in NGS variant calling analysis while participating in retrospective research of clinical oncology data. This position will report to the Assistant Director, Clinical Oncology Informatics. We anticipate that this position will be remote through June 2021.


Key Responsibilities include (but are not limited to):

  • Analyzing sequencing data using established pipelines.
  • Contributing to the update, management and maintenance of next generation sequencing (NGS) data analysis pipelines.
  • Collaborating and consulting with external and internal researchers on the analyses of NGS data.
  • Interpret and present clinical NGS based diagnostic results to treating physicians and tumor boards.
  • Developing and implementing innovative computational approaches for the analysis of large sequence datasets and sample cohorts from NGS technologies.
  • Participating in grant application writing.
  • Staying current on innovations in DNA sequencing analysis as related to clinical laboratory practice.

Requirements & Qualifications

  • PhD. in bioinformatics, computational biology, genetics, computer science or similar with a dissertation in a biological, genomics or cancer related field.
  • 3 or more years work experience in bioinformatics with experience in cancer genomics.
  • Experience managing and working with next generation sequencing data required.
  • Extensive knowledge and experience in the use of existing bioinformatics tools and biological databases, as well as familiarity with cloud computing required.
  • Excellent written and verbal communication skills required.
  • Proficiency in python and R required, and one or more programming languages such as Perl, Java, or C/C++ desirable, as well as willingness to learn new programming languages as necessary to collaborate at NYGC.
  • Experience working in Linux and running tasks in a cluster environment required.
  • Experience in the analysis and understanding of disease mechanisms and therapeutic applications.


  • Prior experience working in precision medicine and in a CLIA environment a plus.
  • Extensive publication record in cancer genomics or NGS based cancer applications.
  • Working experience with precision oncology knowledgebases and variant curation methods.
  • Clinical molecular diagnostic report writing and generation.



  • Technical and Professional Skills: Consistently demonstrates skills and knowledge relevant for current role; strives to expand the depth and breadth of technical and professional skills; works with a high level of integrity; exhibits focus and discipline; appropriately prioritizes, manages expectations and delivers on commitments.
  • Collaborative & Communicative: Models collaboration and teamwork; brings out the best in others; effectively works with all levels, internally and externally; respects and embraces diversity of perspective; communicates clearly and listens carefully; uses good judgment as to what to communicate and when to do so.
  • Adaptable & Innovative: Adaptable and embraces change; develops new insights and pursues improvements and efficiency; fosters exchange of new ideas and willing to challenge the status quo; takes initiative and is solution-oriented; engages in work with passion and curiosity.

FLSA Status – Exempt 

This position is eligible for visa sponsorship and relocation assistance. 

How to Apply
About Our Organization

About the New York Genome Center

The New York Genome Center (NYGC) is an independent, nonprofit, academic research organization dedicated to advancing genomic research. NYGC scientists and staff are furthering new approaches to diagnosing and treating neurological diseases and cancer through their unique capabilities in whole genome sequencing, RNA sequencing, state-of-the art analytics, and the development of genomic tools. NYGC concentrates specifically on disease-based research in the following areas: neuropsychiatric disease (autism, schizophrenia, bipolar); neurodegenerative disease (ALS, Alzheimer’s, Parkinson’s, Huntington’s), and cancer.


Located in Lower Manhattan, the New York Genome Center was founded by and remains closely affiliated with twelve leading academic medical centers and research universities in the New York region and beyond, engaging in research projects with and for these institutions. Essential to our collaborative work is an outstanding faculty, whose members typically hold a joint appointment at NYGC and a partner university. They support our scientific mission by conducting independent research in areas of mutual interest to us and the wider scientific community.

Equal Opportunity 

Diversity, equity, and inclusion are central to the core mission at the NYGC. We strive to create a workplace environment that is welcoming and fair to all regardless of race, ethnicity, gender, sexual orientation, physical ability, or religion. We believe that when people of various backgrounds, life experiences, and perspectives work together in an inclusive and equitable environment we gain new and valuable perspectives that otherwise would have been missed. Valuing and supporting all NYGC employees as individuals while helping them realize their full potential is critical to promoting greater collaboration, innovation, and discovery – fostering a sense of belonging for our greatest strength, our people. We recognize that there is still work to be done that will require sustained commitment from the entire organization.

The New York Genome Center is a VEVRAA Federal Contractor. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, creed, color, gender, religion, national origin, sexual orientation, age, disability, genetic predisposition or carrier status, protected veteran or military status, domestic violence victim status, partnership status, caregiver status, alienage or citizenship status, marital status, or any other characteristic protected by applicable law. The New York Genome Center takes affirmative action in support of its policy to hire and advance in employment individuals who are minorities, women, protected veterans, and individuals with disabilities. 

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