Bioinformatics Scientist

The Children's Hospital Research Institute of Manitoba and the University of Manitoba
Job Location
Winnipeg, MB

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Job Description

The successful candidate will work within a team in a multidisciplinary environment. The work will apply bioinformatics data analysis under the supervision of a senior bioinformatician. The work will focus on determining whether exposure to diabetes in utero is associated with altered DNA methylation patterns at birth. The work will include Methyl Seq data quality check and data normalization, methylated CpG island detection, differentially methylated region discovery, annotation of DMRs for overlap with genomic features such as promoters, CpG islands and single nucleotide polymorphisms (SNPs) that reside within the DMR enhancer, as well as functional annotation and gene ontology pathway analysis by DAVID and function enrichment analysis by GSEA. This work will include modeling of the correlation in differential DNA methylation with obesity or obesity-related complications such as hypertension and type 2 diabetes etc, or with possible confounders such as maternal BMI, gestational age, parity or smoking, or in the offspring sex, current diet, activity levels.


Candidates should have a strong background in bioinformatics or computational biology, have the ability to work independently and within a dynamic collaborative and multidisciplinary environment, possess excellent communication and organizational skills, deliver according to deadlines and milestones, and have a proven track record of productivity. A PhD or prior experience manipulating NGS datasets is a requirement. Familiarity with biology and/or biochemistry and some computer hardware awareness is an asset. Good command of English language and a willingness to travel for training are vital for collaboration with members of our team.

How to Apply

The Children's Hospital Research Institute of Manitoba and the University of Manitoba are committed to creating a diverse and inclusive workplace. Applications are encouraged from qualified applicants including members of visible minorities, Aboriginal peoples, people with disabilities, people of all sexual orientations and genders, and others who may contribute to the further diversification of the university. All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Interested individuals should submit a cover letter, curriculum vitae, and include the contact details of three suggested referees to Dr. Jim Davie, Children's Hospital Research Institute of Manitoba, 715 McDermot Avenue, Room 600A, Winnipeg, Manitoba, R3E 3P4, Canada or


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