NIST has open positions for postdocs to work toward developing the critical resources that will let genomics continue to scale and meet its promise in clinical applications.
The National Research Council sponsors competitive (~10% acceptance rate) 2-year postdoctoral fellowships at NIST, and we are recruiting candidates for positions in the Genome-Scale Measurements group. The opportunity is described at: http://nrc58.nas.edu/RAPLab10/Opportunity/Opportunity.aspx?LabCode=50&ROPCD=506441&RONum=B7844. Proposal deadlines are biannual, on August 1 and February 1. We would welcome proposals for the August 1, 2015 deadline. Please feel free to have candidates contact us directly.
Our group has hosted the Genome in a Bottle Consortium to create well-characterized human genomes as NIST Reference Materials (see http://tinyurl.com/giabpilot, http://www.genomeinabottle.org and http://go.nature.com/utlGz6). These genomes are being rapidly adopted for benchmarking by clinical and research labs (e.g., see https://scholar.google.com/scholar?oi=bibs&hl=en&cites=2229422087673203010). These reference material genomes are also being to develop, refine, and optimize new sequencing technologies and methods.
Proposals could address a near-term opportunity using the unique collection of human sequencing data we are collecting on a trio as part of the Genome in a Bottle Consortium, including 130x PacBio, 900x Illumina, moleculo, 10X Genomics, mate-pair, Complete Genomics, Ion, Oxford Nanopore, and BioNano mapping. A proposal might describe the best-possible assemblies and characterization of this family trio, including small variants, structural variants, and phasing. Alternate proposals might describe use of the well-characterized genomes and machine learning to understand performance of different sequencing and bioinformatics methods to understand biases in any sequenced genome. This could build on benchmarking work like the GCAT tool (http://www.nature.com/ncomms/2015/150225/ncomms7275/full/ncomms7275.html) being done with the Benchmarking Team we chair in the Global Alliance for Genomics and Health. We welcome all proposals related to this work, as well as other ideas related to improving and assessing performance of genomics measurements and precision medicine.