The Foundation for the National Institutes of Health (FNIH) is seeking a bioinformatics and data management consultant to assist in evaluating and managing the construction of a large-scale, public, web-based “information portal” to support effective identification and validation of new drug targets in Type 2 diabetes.
The portal is being developed through an exciting new public-private biomedical research collaboration, the Accelerating Medicines Partnership (AMP), which is being managed by the FNIH and involves the NIH, FDA, and multiple pharmaceutical companies. The AMP Type 2 Diabetes (T2D) Initiative seeks to create an integrated database of DNA sequence, functional genomic, epigenomic, and clinical data from existing studies on T2D and its cardiac and renal complications across roughly 100,000 – 150,000 individuals. The knowledge portal will house the dataset(s) and analytical tools to query and mine the data and will be publicly accessible for interrogation by academic and industry researchers. The project will also seek to collect new data and execute specific targeted data analyses, the results of which will be added to the portal. The end goal will be to have a powerful, publicly available tool that provides access to a comprehensive and dynamic database that will facilitate the rational identification and validation of effective and successful T2D drug candidates and related research objectives.
The Bioinformatics Consultant will provide expert advice and support to the FNIH and the AMP Type 2 Diabetes Steering Committee on the information technology aspects of creating the portal, including vendor and partner selection for the design, build, test, and maintenance phases of portal development.
The consultant will:
- Assist with the review of proposals received in response to the FNIH Accelerating Medicines Partnership Type 2 Diabetes (T2D) Requests for Proposals (RFPs): http://fnih.org/work/key-initiatives/amp-type2-diabetes) for the design and build of the AMP T2D Knowledge Portal with genetics data.
- Help FNIH assess the ongoing progress of the development of the portal, including database and communications, as well as user interface aspects of the design.
- Interact with a multi-stakeholder project team including clinicians, statisticians and computer scientists from the academic, government, and private sectors.
- Advise FNIH and its grantees on expanding the portal functionality to answer various gene variant-related questions around T2D risk and protection, eQTLs in relevant tissues, T2D-related complications, and epigenetics.