Bioinformatics Analyst I

Organization
Baylor College of Medicine Human Genome Sequencing Center
Job Location
One Baylor Plaza
Houston, TX 77030
Job Description

This entry-level position requires a bioinformatics programmer with experience dealing with large data sets. The Next-Generation Sequencing Informatics (NGSI) group manages the production, maintenance and primary analysis of vast quantities of genome sequence data as well as collaborating internationally on large cohort sequencing studies, specifically in the area of large-scale small and structural variant calling. Under the direction of a senior manager, a qualified candidate will assist with the processing and analysis of these data.

Duties

  • Running bioinformatics analyses on heterogeneous data on a local HPC cluster.
  • Tracking and managing jobs and storage efficiently.
  • Using cloud computing to analyze large data sets.
  • Processing and analysis of data within a Hadoop data warehouse.
  • Performs other job-related duties as assigned.
Requirements
  1. B.S/M.S. in Bioinformatics/Computer Science/IT/Biology with 1-2 years of related work experience
  2. Linux background with at least 2 yrs hands-on experience working on Unix/Linux terminal

  3. At least 1 year of programming experience with Python (preferred) or Java.
  4. Familiar with running analyses on HPC cluster (Moab, PBS, Torque preferred)
  5. Demonstrated ability to manage multiple tasks and overlapping deadlines
  6. Experience with Next-Gen Sequencing analysis tools and workflows (Mercury, BWA, vcftools, BEDtools, bamUtils, SAMtools, Picard, etc.)
  7. Experience handling/manipulating common data formats in genomics (FASTA, FASTQ, BAM, VCF, etc)
  8. Excellent communication skills, both written and verbal, is required
  9. Understanding of biological processes and genomics a plus

Desirable Skills and Experience:

Education:  BS/MS in Bioinformatics, IT, Computer Science, Biology or equivalent experience.

Preferred:

  • Prior next-gen sequencing data analysis experience
  • Prior experience in database analysis
  • Prior experience with structural variation detection

Minimum Education: BS

Minimum Job Experience: 1 year

About Our Organization

The Baylor College of Medicine Human Genome Sequencing Center (HGSC) was founded in 1996 under the leadership of Dr. Richard Gibbs and is a world leader in genomics. The fundamental interests of the HGSC are in advancing biology and genetics by improved genome technologies. As one of the three large-scale sequencing centers funded by the National Institutes of Health, the HGSC provides a unique opportunity to work on the cutting-edge of genomic science in a state of the art institution. Today, the HGSC employs ~ 200 staff, and it occupies more than 36,000 square feet on the 14th, 15th, and 16th floors of the Margaret M. and Albert B. Alkek Building. The HGSC is located on the southwest edge of downtown Houston, the fourth largest city in the U.S., in the Texas Medical Center, the world's largest medical complex. The major activity of the HGSC is high-throughput DNA sequence generation and the accompanying analysis. The HGSC is also involved in developing the next generation of DNA sequencing and bioinformatics technologies that will allow greater scientific advances in the future.

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