Bioinformatician position (single cell analysis) at Institut Curie/ESPCI (Paris, France)

Organization
Institut Curie
Job Location
26 Rue d'Ulm
75005 Paris
France
Benefits

COD (French contract dedicated to a specific project)– 2 years, eventually followed by a permanent position depending on success. The salary will depend on profile and experience.

Job Description

We are developing a prototype droplet-based microfluidics system for single-cell transcriptomic, epigenetic and phenotypic analysisas well as paired TCR α-β chain sequencing of immune cells. 

Cancer is the second leading cause of death globally, and is responsible for an estimated 9.6 million deaths in 2018. Globally, about 1 in 6 deaths is due to cancer. Despite the improved patient survival achieved with the advent of immunotherapies, about 60-70% of patients don’t respond to treatment or relapse later on. This underscores the need for understanding the evasion/resistance immune mechanisms within the tumor microenvironment (including myeloid cells and T lymphocytes) that hinder an effective anti-tumor immunity. 

This powerful droplet-based microfluidics system will provide unprecedented information on single-cell heterogeneity of tumor-infiltrating immune cells and the complexity of their interactions with other cells within the tumor, thereby paving the way for cancer biomarker and therapeutic target discovery.

The candidate will apply bioinformatics analysis on transcriptomic (scRNA-Seq), epigenetic (scChIP-Seq) and phenotypic (Ab-Seq) data to improve our understanding of the evasion/resistance immune mechanisms within the tumor microenvironment. 

 

In close collaboration with wet lab postdocs and students, he/she will help design experiments and will be in charge of integrating and interpreting comprehensive next generation sequencing datasets:

- Single-cell next-Generation Sequencing data (including ChIP-Seq and RNA-Seq)

- Pathways and Enrichment analyses (Networks, Functional, Transcription Factor Binding Sites…).

He/she will benefit from strong interactions within the bioinformatics team in the “Immunity and Cancer” unit headed by Sebastian Amigorena (15 people) and in the LBC/ESPCI headed by Andrew Griffiths (25 people)

Requirements

The candidate should have a PhD in bioinformatics/computational biology or in a relevant biological field with quantitative/computational experience, and a strong interest in immunology. He should ideally have skills in statistics. We expect strong curiosity and motivation to work with and for others.

How to Apply

Applications will be continually reviewed and should be submitted by email to Silvia Lopez-Lastra (silvia.lopez-lastra@curie.fr) and Stéphanie Toetsch (stephanie.toetsch@espci.fr) and include a CV, research experience and interests, and the names and e-mail addresses of three referees.

About Our Organization

Institut Curie is one of the biggest European institutions for cancer research with strong and interdisciplinary traditions. It also comprises a hospital specialized in cancer treatment, and therefore disposes of a continuum of expertise from basic research to patient care. Our immunology unit includes 10 independent research teams in the fields of basic and applied immunology, working in a very collaborative and international environment. The open position is in line with recent developments and an effort to strengthen the interface between immunology single-cell technologies and bioinformatics. The postdoctoral fellow will be co-supervised by S. Amigorena and Prof. A Griffiths, director of the Laboratory of Biochemistry (LBC) at the ESPCI. The research activities of LBC are based around droplet-based microfluidics, a powerful new ultrahigh-throughput system in which reaction volumes can be miniaturized by up to a million-fold compared to conventional assays in microtiter plates. Both institutes, Curie and ESPCI, are located in the center of Paris, in a both cultural and scientific rich environment. The successful candidate will be mainly located at the Institut Curie (Amigorena’s lab).

This position is supported by DIM ELICIT “Empowering LIfe sCiences with Innovative Technologies” funding. 

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