Bioinformatician II - Program in Systems Biology

Organization
UMass Medical School
Job Location
Worcester, MA 01605
Job Description

GENERAL SUMMARY OF POSITION:

Welcome to the Program in Systems Biology at the University of Massachusetts Medical School. Our program is one of the newest initiatives on campus and aims to explore the mechanisms and principles of biological complexity. This is an exciting time for systems biology, with rapid technological advances in many fields including genomics, computational biology, imaging, mass-spectroscopy and bioinformatics. Research in the program develops and leverages technological breakthroughs in these areas to explore the biology of complex systems. Today’s scientific research in general, and systems biology in particular, is increasingly multi-disciplinary. Therefore, we aim to create an intellectually diverse environment where combining different fields is encouraged and where students, post-doctoral fellows and faculty from different backgrounds work together in a collegial and interactive atmosphere.

 

GENERAL SUMMARY OF POSITION:

Under the general direction of faculty, the Bioinformatician level II is responsible for the design, development, evaluation and iterative modification of a technical infrastructure to expedite the quantitative evaluation of data resulting from studies that are laboratory based. The position will entail the establishment and maintenance of applicable in-house bioinformatics resources and interaction with individual lab members on customized research projects, as well independent projects that are solely computational. All functions will be under the guidance and direction of the P/I and a senior memebr of the team.

 

The Bioinformatician will also be responsible for conducting the following duties:

 

  • Generate customized programming solutions to improve user interaction with available bioinformatics resources
  • Implementation and adaptation of programs for high-throughput sequencing data analysis, statistical analysis of data and for data visualization
  • Develop, implement and maintain custom designed computational solutions relevant for ongoing lab-based projects
  • Develop, implement and maintain computational methods for meta-analysis of data generated in the lab as well as publicly available data
  • Interact with a high-performance computing cluster (LSF) to schedule standard data processing pipelines and data analysis workflows

 

 

 

 

 

Requirements

MAJOR RESPONSIBILITIES:

  • Establish general bioinformatics resources for day-to-day use by members of the laboratory.
  • In collaboration with a member of the faculty, generate customized programming solutions to improve user interaction with available bioinformatics resources
  • Implement and adapt programs for microarray analysis, high-throughput sequencing data analysis, cis regulatory motif identification, and multi-genome protein motif searches.
  • Independently develop, implement and maintain custom designed computational solutions relevant for ongoing lab-based projects.
  • Independently develop, implement and maintain computational methods for meta-analysis of data generated in the lab as well as publicly available data.
  • Independently execute a scientific computational project (e.g. a project that can result in a first author publication)
  • Supervise entry level bioinformaticians.
  • Local establishment and customization of model organism genomic databases and tools for batch sequence analysis utilizing these resources.
  • Interpret and present study results in support of laboratory members.
  • Provide tabular and written summaries of approaches and analyses in a form suitable for inclusion in manuscripts or grant applications, as well as media for presentation at scientific meetings
  • Develop and implement custom bioinformatics programming solutions in collaboration with lab as necessary
  • Coordinate and collaborate with other research computing expertise at the Medical School as necessary
  • Participate in conference calls and data management meetings as needed
  • Perform other duties as required

REQUIRED QUALIFICATIONS:

  • BS in computer science, or equivalent experience
  • 2 years of experience in relevant setting
  • Co-authorships on peer-reviewed publications are strongly suggested but not required
  • Strong background in statistical methodology, software languages and computer systems (Perl, C++, R, MySQL, etc.)
  • Experience in writing basic search algorithms and the ability to generate new algorithms and programs for custom data manipulation and analysis
  • Excellent communication skills, both oral and written, and interpersonal skills necessary to interact with a wide range of individuals.

 

UMass Medical School is committed to being an equal opportunity and affirmative action employer and recognizes the power of a diverse community. We encourage applications from protected veterans, individuals with disabilities and those with varied experiences, perspectives and backgrounds to consider UMass Medical School as their employer of choice.

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