Bioinformatician - Genomics

Organization
University of Cambridge
Job Location
University of Cambridge
Box 111 Cambridge Biomedical Campus
Cambridge
Cambridgeshire
CB20SP
United Kingdom
Salary
£29, 301 to £38,183
Job Description

This new role is based in the MRC Mitochondrial Biology Unit within the Cambridge Institute for Medical Research building on the Biomedical Campus, and will involve close collaboration with bioinformatic teams at Cambridge University, notably within the Stem Cell Institute, and also with collaborating groups at the European Bioinformatics Institute and The Wellcome Trust Sanger Centre.

The role holder will use existing and new bioinformatic tools to analyse and interpret high throughput transcriptome data generated using state of the art single cell approaches in collaboration with the Cambridge single cell unit.  The over-arching aim of the project is to understand how mitochondria communicate with the cell nucleus during development and in disease.  Data sets will include whole genome, RNA Seq and Bisulfite sequencing enabling integrated multiomic analysis to address questions of fundamental biological importance including the role of oxidative metabolism during mammalian development and in late onset neurological disorders including Alzheimer’s Disease and Parkinson’s Disease.

The role holder will be closely integrated with a multi-disciplinary research group enabling the close interaction between the informatics team and both biologists and clinicians.  In addition to their own research project there will be opportunities for training and development.

The role holder will be based in the Mitochondrial Biology Unit within Professor Chinnery’s research group.  The over-arching aim of the research group is to understand the role of mitochondrial diseases with a view to developing new treatments using a combination of genomic, cell biology, informatic techniques, human tissues and cell and animal models.  The Chinnery group publishes between 40 and 50 papers a year including recent high profile papers in Nature Genetics and the Journal of the American Medical Association.   The role holder will join the Bioinformatics team at the Mitochondrial Biology Unit which includes over 10 informaticians, providing close support and the opportunity to engage more widely within the research environment.

Requirements
  • Educated to degree level in a scientific discipline (e.g. bioinformatics, computer science or biological science)

  • Post graduate education or significant or extensive experience in data management, bioinformatics or computational biology (e.g. MPhil in Computational Biology)

  • Programming - Working knowledge of programming languages in Bioinformatics (Perl and/or Python, Java), cluster computing and software deployment
  • Sequence bioinformatics – Experience with sequenced-based analysis, next generation sequencing data, annotation, browsers, alignment tools etc.
  • Genomics – Experience with and understanding of concepts, theories and methods for analysis genomes
  • Data analysis - Ability to data manipulation, curating and auditing methodologies
  • System design, testing, implementation and documentation
  • Collation, analysis and dissemination of strategic and technical information
How to Apply

Please apply online through the University job pages: http://www.jobs.cam.ac.uk/job/11596/

About Our Organization

The University of Cambridge is one of the world’s oldest and most successful Universities, with an outstanding reputation for academic achievement and research. It was ranked first in the 2011 QS World University Rankings and its graduates have won more Nobel Prizes than any other university in the world. The University comprises more than 150 departments, faculties, schools and other institutions, plus a central administration and 31 independent and autonomous colleges.

The University and the Colleges are linked in a complex historical relationship. The Colleges are self-governing, separate legal entities which appoint their own staff. They admit students, provide student accommodation and deliver small group teaching (supervisions). The University awards degrees and its faculties and departments provide lectures and seminars for students, determine the syllabi for teaching and conduct research.

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