This new role is based in the MRC Mitochondrial Biology Unit within the Cambridge Institute for Medical Research building on the Biomedical Campus, and will involve close collaboration with bioinformatic teams at Cambridge University, notably within the Stem Cell Institute, and also with collaborating groups at the European Bioinformatics Institute and The Wellcome Trust Sanger Centre.
The role holder will use existing and new bioinformatic tools to analyse and interpret high throughput transcriptome data generated using state of the art single cell approaches in collaboration with the Cambridge single cell unit. The over-arching aim of the project is to understand how mitochondria communicate with the cell nucleus during development and in disease. Data sets will include whole genome, RNA Seq and Bisulfite sequencing enabling integrated multiomic analysis to address questions of fundamental biological importance including the role of oxidative metabolism during mammalian development and in late onset neurological disorders including Alzheimer’s Disease and Parkinson’s Disease.
The role holder will be closely integrated with a multi-disciplinary research group enabling the close interaction between the informatics team and both biologists and clinicians. In addition to their own research project there will be opportunities for training and development.
The role holder will be based in the Mitochondrial Biology Unit within Professor Chinnery’s research group. The over-arching aim of the research group is to understand the role of mitochondrial diseases with a view to developing new treatments using a combination of genomic, cell biology, informatic techniques, human tissues and cell and animal models. The Chinnery group publishes between 40 and 50 papers a year including recent high profile papers in Nature Genetics and the Journal of the American Medical Association. The role holder will join the Bioinformatics team at the Mitochondrial Biology Unit which includes over 10 informaticians, providing close support and the opportunity to engage more widely within the research environment.