The Ensembl Regulation team seeks an enthusiastic bioinformatician to join the team and contribute to the annotation of regulatory elements across the genome and across cell types.
Ensembl is one of the most successful large-scale bioinformatics projects and one of the leading providers of genome annotation. We import massive amounts of data from various archives (genome sequences, variation archives etc.) and use them to create syntheses (gene annotation, whole-genome alignments, gene trees, regulatory elements etc.). Our services are freely open to all scientists around the world and serve a range of uses, from basic science to biomedical research.
Ensembl Regulation is specialised in epigenomic and cis-regulatory datasets, which are used to define the Ensembl Regulatory Build. This annotation highlights the regulatory regions of the genome that control when genes are expressed and in which tissues. These elements have been shown to play a significant role in explaining the mechanisms underlying evolution as well as disease. You will work alongside the existing developers and:
- Incorporate more public databases into our existing database, thus extending our coverage of cell types, tissues and species;
- Implement new bioinformatics pipelines to process different assay types (e.g. DNA methylation and Hi-C);
- Perform various downstream analyses (e.g. differential analysis of epigenetic signatures);
- Support international and regional consortia (e.g. IHEC, FAANG) by processing their data and providing expertise;
- Help out users of the Ensembl website and APIs and develop new features or tools to make their research more efficient;
- Extend the current MySQL database schemas and the Perl API to handle new data types/results;
Ensembl Regulation (led by Myrto Kostadima) is a component of the Genome Analysis team (led by Daniel Zerbino), which is itself part of Ensembl (led by Paul Flicek).