The Ensembl Regulation team seeks an enthusiastic and talented bioinformatician to join the team and contribute to the annotation of regulatory elements across the genome in different cell types and species.
Ensembl is one of the most successful large-scale bioinformatics projects and one of the leading providers of genome annotation. As large-scale sequencing projects are producing genomic data on an unprecedented scale, the Ensembl team aggregates, re-processes and annotates large quantities of data from public archives and develops tools for data access. Ensembl Regulation specialises in epigenomic and cis-regulatory datasets, which are used to define the Ensembl Regulatory Build.
Your main responsibilities include:
- Maintaining and running our production pipelines on a high performance computing cluster to download, process and integrate new data sets for the functional annotation of new cell types or species;
- Developing new bioinformatic pipelines to process data sets from different epigenetic assays, such as DNA methylation and Hi-C;
- Documenting the data and processes used for the annotation of regulatory elements;
- Extending and maintaining the current MySQL database schemas and the Perl and REST API to handle new data types and results;
- Collaborating with international and regional consortia (e.g. IHEC, FAANG) to process epigenomic data, provide support and expertise and develop new features or tools to make their research more efficient;
- Teaching API courses, providing user support for the Ensembl website and APIs and presenting at conferences;
- Liaising with members of the broader Ensembl team and other groups at EMBL-EBI.
The Ensembl Regulation project is a component of the Genome Analysis team. You will join a team of four bioinformaticians who have domain area expertise in public archives, alignment methods, software development, large-scale compute, pipeline workflows and automation. Future projects for the team include: scaling up gene regulation annotation pipelines and our data set import pipeline and developing methods of analysing new data including ATAC-seq and DNA methylation.
This is a unique opportunity to contribute to Ensembl’s mission to analyse, store and disseminate genomic annotation. For further information about Ensembl, please visit: www.ensembl.org and https://github.com/Ensembl.
For further information about the Ensembl Regulatory Build please visit: