Associate Scientist I/II – Human T Cell Cancer Immunologist

Job Location
Gaithersburg, MD
Job Description

If you're inspired by the possibilities of science to change lives and you thrive when making brave decisions - join us.
MedImmune is the worldwide biologics research and development arm of AstraZeneca. Here, you'll have the opportunity to make a difference in people's lives every day. As one of the world's premier biotechnology companies, our mission is centered on delivering life-changing products that advance world health, and help fight and cure disease.  As an  Associate Scientist I/II - Human T Cell Cancer Immunologist n Gaithersburg, MD, you'll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients' lives.
We're constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We're pioneering innovative research and exploring novel pathways across key therapeutic areas including oncology, respiratory, inflammation and autoimmunity, cardiovascular and metabolic disease, and infection and vaccines. And we're industry-leading in immunology, protein engineering and translational science. We offer a unique and strong collaborative network as part of the AstraZeneca family, as together we explore synergies between small and large molecules.
MedImmune has a dynamic environment that fosters collaboration and innovation. We attract top minds, and we nurture and build top talent.


Main Duties and Responsibilities 
The successful candidate will be an integral part of a team whose goal is to design and develop novel cancer immunotherapies directed against shared and neo-antigens. The position will focus on the discovery and validation of targets for T cell-based immune-therapies with a specific emphasis on MHC-class I bound peptide targets for multiple haplotypes. They will be responsible for developing and executing novel cell-based assays and the in depth evaluation of T cell specificities. This position will also play a critical role in developing assays that become part of the clinical evaluation of therapeutic vaccines. The candidate will need to work effectively as part of a team and independently within their role.
Essential Requirements 
Required Experience:

•The successful candidate will have general knowledge of the field of Human T Cell Immunology.
•The ideal candidate will have in-depth experience with the phenotypic and functional assessment of human T cells.
•Extensive experience with multi-color flow cytometry is required.
•Experience performing standard laboratory procedures for the study of cellular immune responses (e.g. ELISpot, Luminex, ELISA, etc.) and the isolation of human lymphocytes from peripheral blood and tumor biopsies.
•Ability to prepare precise protocols, quantitative analyses, technical reports, and maintain appropriate documentation.
•Strong verbal and written communication skills.
•Highly organized, with the ability to develop focused work packages, prioritize based on defined goals, and work both independently and as part of a team.
•The candidate should be able to define critical scientific questions/hypothesis and address them through the design and execution of controlled experimentation. 
Preferred Experience:

•Experience developing pharmaceuticals that target T cell function and/or therapeutic vaccines for oncology or chronic infections.
•Experience identifying TCR specificities (e.g. epitope mapping), affinities, and sequences.
•Experience with biochemical and/or molecular biology techniques (e.g. Western Blot, cloning, qPCR, etc.) 

•B.S. or MS in Biology, Immunology, Oncology or related field. 
Relevant work experience:

•Associate Scientist I - B.S. 5-8 years, M.S. 2-5 years
•Associate Scientist II - B.S. 8-10 years, M.S. 5-8 years 
Next Steps - Apply today! 
To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience - it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity.  If you know someone who would be a great fit, please share this posting with them.
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. 

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