Associate Scientist II / Scientist I, Translational Pathology

Job Location
1500 Seaport Blvd
South San Francisco, CA 94063
Job Description

Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products - Imbruvica, Venclexta, and Empliciti - and a pipeline containing multiple promising new molecules that are being studied in nearly 200 clinical trials in 19 different types of cancer.
AbbVie is expanding its oncology hub on the West Coast, with three sites in the San Francisco Bay Area (Redwood City, South San Francisco, and Sunnyvale) focused on the discovery and development of novel oncology therapies. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work across these three sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. This position is based at Stemcentrx, AbbVie's South San Francisco, CA location. 
We are seeking a highly motivated individual with biochemistry and cell biology lab experience to work within the Translational Pathology Group to support tissue-based companion diagnostic development. This position will be involved in the generation of high quality biochemical data (western blot, ELISA/MSD, Flow cytometry) to accurately characterize protein expression in cell lines and tissues. The individual will interact with members of the Translational Pathology team as well as members of other research functions and the bioinformatics group to generate, analyze, bank, and track control reagents. The successful candidate will have familiarity with mammalian cell culture techniques, preparation of cell and tissue lysates, SDS-PAGE, and western blotting. A familiarity with transfection for the purposes of overexpression and gene expression knockdown/knockout is preferred. Familiarity with RNA isolation and assessment of gene expression via QRTPCR (TaqMan) are also beneficial.
Key Responsibilities: 

• Cell culture. Candidate should have demonstrated experience in standard cell culture techniques, including culture of adherent and non-adherent cell lines and cell banking. 
• SDS/PAGE & Western Blotting. Candidate should have experience in preparing lysates from cells and tissues for the purpose of western blotting and other protein based assays, such as ELISA and MSD. 
• Candidate will be responsible for the curation and management of the samples prepared for protein analysis, as a resource for the Translational Pathology group. 


Associate Scientist II: Bachelor's Degree, or equivalent education, with typically 3 or more years' experience or Master's Degree or equivalent education.
Scientist I: Bachelor's Degree or equivalent education with typically 5 years of experience, or Master's Degree or equivalent education with typically two years of experience.

• Experience with standard cell culture techniques. 
• Experience with transfection and cell lysate preparation. 
• Experience with SDS-PAGE and western blotting. 
• Ability to design experiments, analyze and interpret data and communicate results independently 
• Excellent verbal communication and interpersonal skills are required; must be able to multi-task and participate in highly effective teams 
• Strong motivation, attention to detail, and ability to think independently and fully integrate into a high achieving team environment 

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